Current Research & Innovations

Vascular

• Abdominal Aortic Aneurism (AAA): Evaluating Talent Endograft (IDE/Medtronic) —This study evaluates the safety and efficacy of Talent Endograft for abdominal aortic aneurisms. (James McKinsey, MD)
• Abdominal Aortic, Aorto-Iliac, and Iliac Aneurysms: Evaluating the Aorfix Stent Graft (PYTHAGORAS/Lombard) —This study evaluates the safety and efficacy of the Lombard Medical bifurcated endovascular stent graft (Aorfix) in the treatment of abdominal aortic, aorto-iliac and common iliac aneurysms with necks of up to 60 degrees. (James McKinsey, MD)
• Assessing the Effect of Simvastatin, Losartan, or Pioglitazone after Six Weeks of Treatment for Peripheral Arterial Disease (LEAP/Fox Hollow) —The purpose of this study is to assess the effect of six weeks of treatment with simvastatin, losartan or pioglitazone on the RNA expression profile of atherosclerotic plaque excised from peripheral arteries in the lower extremity of patients with peripheral arterial disease. (James McKinsey, MD)
• Atherosclerosis and Lung Function: A Multi-Ethnic Study —This study focuses on predictors of lung function across different ethnic groups, including atherosclerosis, endothelial dysfunction, and biomarkers. (Steven Kawut, MD, MS)
• Carotid Artery Stenosis: Comparing the Xact RX Stent and Emboshield Cerebral Protection System with Carotid Endarterectomy (ACT I/Abbott) —The purpose of this study is to demonstrate that carotid artery stenting using the Xact RX stent with the Emboshield Cerebral Protection System is equivalent to carotid endarterectomy (CEA) in treating carotid stenosis. (William Gray, MD)
• Carotid Artery Stenosis: Evaluating the Bard ViVEXX Carotid Stent and Emboshield BareWire Rapid Exchange Embolic Protection System (VIVA/Bard) —This study evaluates the safety and efficacy of the Bard ViVEXX carotid stent and Emboshield BareWire Rapid Exhange Embolic Protection System in the treatment of carotid artery stenosis (narrowing of the artery that supplies blood to the brain). (James McKinsey, MD)
• Carotid Artery Stenosis: Evaluating the Safety of RX ACCULINK and RX ACCUNET (CAPTURE II/Guidant) —This study will collect evidence that the RX ACCULINK carotid stent system and the RX ACCUNET embolic protection system can be used safely by a wide range of physicians in commercial conditions. (Issam Moussa, MD)
• Carotid Endarterectomy (CEA): Predicting Outcomes with Non-Invasive Ultrasound (DVA/New Health Sciences) —This study evaluates whether data derived from non-invasive transcranial Doppler ultrasound can predict outcomes following carotid endarterectomy (surgery to remove the lining of the carotid artery that has become thickened or damaged). (James McKinsey, MD)
• Cognitive Impact of Carotid Endarterectomy (CEA) —This study has enrolled numerous patients at Columbia and has recently become available at Cornell. Most open carotid cases can be enrolled. The study examines pre- and postoperative cognitive function and transcranial Doppler assessment. Available to essentially all patients undergoing carotid enderarterectomy. (James McKinsey, MD)
• Comparing Carotid Stents and Carotid Endarterectomy (CREST/NIH) —This study compares carotid stenting and carotid endarterectomy (CEA). (William Gray, MD)
• Comparing the Zilver PTX Drug-Eluting Vascular Stent to Percutaneous Transluminal Angioplasty (Zilver PTX/Cook) —This study compares the long term safety and effectiveness of the Zilver PTX Drug-Eluting Vascular Stent to percutaneous transluminal angioplasty. (Nicholas Morrisey, MD)
• Critical Limb Ischemia (CLI): Comparing Catheter-Based Plaque Excision with Bypass Surgery (PROOF/Fox Hollow) —This study compares the outcomes of catheter-based plaque excision to the outcomes of bypass surgery for the treatment of patients with critical limb ischemia (a severe form of peripheral arterial disease in which obstruction of arteries decreases blood flow to the limbs). (James McKinsey, MD)
• Diabetic Foot Ulcers: Evaluating Dermal-LSR with Standard of Care (SOC) Treatment (Sanofi-Aventis) —The purpose of this study is to compare the effectiveness of Dermal-LSR and standard of care (SOC) with the effectiveness of SOC alone in the treatment of chronic diabetic foot ulcers. (Nicholas Morrisey, MD)
• Endovascular Exclusion of AAA in High Risk Patients with Large Aortic and Iliac Artery Anatomy — (James McKinsey, MD)
• EXACT/Abbott —To collect data on the FDA 510(k) cleared Embolished BareWire Rapid Exchange Embolic Protection System and FDA approved Xact Rapid Exchange Cartotid Stent System when used under commercial use conditions by a broad group of physicians (James McKinsey, MD)
• Peripheral Artery Disease: Establishing the Safety of the Orbital Atherectomy System (OASIS/Cardiovascular Systems, Inc.) —The purpose of this study is to establish patient safety and the acute procedural effectiveness of the Orbital Atherectomy System in debulking stenotic lesions in the treatment of symptomatic patients with occlusive peripheral arterial disease. (James McKinsey, MD)
• Renal Disease: Evaluating the Safety and Effectiveness of the Fusion Vascular Access Graft (ACCESS) —This study evaluates the safety and effectiveness of the Fusion Vascular Access Graft, a graft that may be used within 72 hours of implantation. (Nicholas Morrisey, MD)
• Small Abdominal Aortic Aneurisms (AAA): Observation vs. Early Endovascular Repair (PIVOTAL/Medtronic) —This study evaluates whether endovascular repair using the AneuRx Stent System is superior to ultrasound surveillance for the management of small (4-5 cm) abdominal aortic aneurysms. ( , )
• SWIFT/ Fox Hollow —To evaluate the safety and effectiveness of the SilverHawk Plaque Excision System for the treatment of de novo femoropopliteal lesions (James McKinsey, MD)
• The ViVEXX Carotid Revascularization Trial — (James McKinsey, MD)
• Thoracoabdominal Aneurysm (TAA): Evaluating Talent Endograft (IDE/Medtronic) —This study evaluates the safety and efficacy of Talent Endograft for thoracoabdominal aneurysms (TAA). ( , )
• Thoracoabdominal Aneurysm (TAA): Evaluating the Zenith TX2 Endovascular Graft (Expanded Access/Cook) —This study evaluates the safety and efficacy of the Zenith TX2 endovascular graft for thoracoabdominal aneurysm. (James McKinsey, MD)
• Venous Stasis Ulcers: Evaluating the PFAB Leg Compressor (SUN Scientific) —The purpose of this study is to evaluate a new technology, the PFAB Leg Compressor, designed to heal venous stasis ulcers more effectively by applying a bandage and compression to the ulcer. (Ross Lyon, MD)
• Zenith TX2 THORACIC TAA Endovascular Graft Clinical Trial Protocol — (James McKinsey, MD)