Current Research & Innovations

Pediatric

• Acute Liver Failure (Pediatrics): Evaluating the Safety and Efficacy of N-Acetylcysteine in the Treatment of Acute Liver Failure Not Caused by Acetaminophen —This multi-center study evaluates the safety and efficacy of N-acetylcysteine in the treatment of acute liver failure not caused by acetaminophen. (Steven Lobritto, MD)
• Advanced Liver Failure (ALF) Pediatric —The Pediatric Acute Liver Failure (PALF) Study is a multi-center, multi-national collaborative study aimed at identifying, characterizing, and developing management strategies for infants, children, and adolescents who present with acute liver failure (ALF). It includes 19 clinical centers and a data coordinating center. The primary focus of the PALF study group is to collect, maintain, analyze, and report clinical, epidemiological, laboratory, and outcome data in children with ALF. Including information derived from biospecimens. (Lobritto Steven, MD)
• Chronic Hepatitis B in Children and Adolescents: Determining the Safety and Efficacy of Adefovir Dipivoxil —This phase III, double-blind, randomized, placebo-controlled study evaluates the safety and efficacy of adefovir dipivoxil in children and adolescents (ages 2 to less than 18) with chronic hepatitis B. (Steven Lobritto, MD)
• Collaborative Investigation of Non-syndromic Cleft Heredity (CINCH) —This is a multi-center trial (Harvard, Columbia, and Vanderbilt Universities) of potential genetic patterns of nonsyndromic cleft lip and/or palate. We hope to study the genetic patterns (polymorphisms) to define potential combinations of polymorphisms that can predict the occurence of cleft lip and/or palate. (June Wu, MD)
• Pediatric Liver Transplant: Collecting Scientific Data —This multi-center, prospective study will collect scientific data on pediatric liver transplantation. (Steven Lobritto, MD)
• Studies of Pediatric Liver Transplantation (SPLIT), a Multi-Center, Prospective Study to Collect Scientific Data on Pediatric Liver Transplantation —Studies of Pediatric Liver Transplant, (SPLIT), is a research effort that was organized in 1995 by a group of physicians and surgeons committed to the success of liver transplants in children. The group represents a collaborative effort between transplant centers in the United States and Canada, and works to collect and analyze information required to advance the science of pediatric liver transplant. (Steven Lobritto, MD)