Current Research & Innovations

Lung Transplant

• Assessment Of Kidney Function in Lung Transplant Candidates — ( , )
• Atherosclerosis and Lung Function: A Multi-Ethnic Study —This study focuses on predictors of lung function across different ethnic groups, including atherosclerosis, endothelial dysfunction, and biomarkers. (Steven Kawut, MD, MS)
• Comparison of a Tacrolimus/Sirolimus/Prednisone Regimen versus Tacrolimus/Aziathioprine/Prednisone Immnosuppressive Regimen in Lung Transplantation —This study is comparing the efficacy of different immunosuppressive regimens after lung transplantation. ( , )
• Exercise Capacity and Survival in Idiopathic Pulmonary Fibrosis — ( , )
• Explaining Racial and Ethnic Disparities in Idiopathic Pulmonary Fibrosis — (David Lederer, MD)
• Genetic Analysis to Predict Rejection of Lung Transplants (Lung Allograft Rejection Study/LARGO) —Utilizing microarray analysis techniques to determine peripheral blood gene expression, this study focuses on the prediction of acute rejection after lung transplantation. ( , )
• Inhaled Cyclosporine for Lung Transplant--MultiCenter, Randomized, controlled Study to Demonstrate the Efficacy and Safety —Cyclosporine inhalation solution (CIS) is a novel therapeutic agent in late-stage development designed to augment the immunosuppression provided directly to the allograft while minimizing systemic exposure and toxicity. The safety and efficacy of CIS in preventing chronic rejection and improving survival has been demonstrated in a randomized, doubleblind, placebo controlled, clinical study (ACS001; Iacono et al, 2006). This study is designed to confirm these findings in a larger multicenter study. (Selim Arcasoy, MD)
• Investigational Therapy May Help Avoid Lung Removal Surgery for Patients with Pleural Mesothelioma —The Mesothelioma Center within the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital and Columbia University Medical Center is now recruiting patients for a clinical research study of a new targeted radiation and chemotherapy protocol for pleural mesothelioma, a cancer of the lung's lining that is almost always caused by previous exposure to asbestos. The standard treatment for pleural mesothelioma is currently surgery to remove the patient's lung — a potentially debilitating consequence. This study will investigate whether a combination of chemotherapy and radiation targeted directly at the lung's lining can improve outcomes while avoiding surgery. Overall, it is hoped that this study will decrease the need for patients to undergo radical surgery. (Robert Taub, MD)
• IVIG Treatment for Acquired Immunodeficiency in Lung Transplant patients: A Randomized Crossover Trial — (Selim Arcasoy, MD)
• Lung Transplant: Genetic Predictors of Primary Graft Dysfunction after Transplant —This study focuses on genetic determinants of primary graft dysfunction after lung transplantation. (Steven Kawut, MD, MS)
• Molecular Monitoring after Solid Organ Transplantation —This study examines which genes are active in patients undergoing lung transplantation. ( , )
• Outcomes after Lung Retransplantation in the Modern Era — ( , )
• Outcomes of Tacrolimus/Imuran Versus Cyclosporine/Mycophenolate Mofetil Therapy with IL-2 Antagonist Induction Therapy Following Lung Transplantation — (Selim Arcasoy, MD)
• Pathogen Discovery in Chronic Lung Disease —This study is focused on microbes present in patients after lung transplantation. ( , )
• Platelet Activation after Lung Transplantation — ( , )
• Risk Factors for Venous Thromboembolism after Lung Transplantation — ( , )
• Role of Activated Protein C in Early Acute Respiratory Distress Syndrome —This study will determine whether levels of activated protein C after lung transplantation are associated with lung allograft function. ( , )