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Home > Patient Guide > Clinical Trials
Clinical Trials: Detail
| Title: | Secretin-Stimulated MRCP as an Early Screening Modality for Pancreatic Ductal Abnormalities in Patients at High Risk for Pancreatic Adenocarcinoma: A Pilot Study |
| Trial Start Date: | 3/19/2008 |
| Trial End Date: | 3/18/2009 |
| Principal Investigator: | Harold Frucht, MD |
| Description: | The aim of our study is to evaluate the utility of SMRCP in detecting carcinoma and precancerous lesions in patients with a significant family history of pancreatic adenocarcinoma. Our hypothesis is that SMRCP is superior to traditional CT or MRI in detecting early pancreatic neoplasms, and approaches the accuracy of EUS. The primary outcome that we will be studying will be concordance of SMRCP and SEUS. Secondarily, we will be measuring positive predictive value of SMRCP, in comparison with EUS and ERCP in identifying neoplasm in those patients who undergo surgical resection during this study |
| Criteria: | Inclusion criteria:
1. 18 years of age and older.
2. At least two first- or
two- second-degree relatives with pancreatic adenocarcinoma (the study subject will be either 10 years younger than the youngest age at which a relative was diagnosed with pancreatic cancer, or the study subject will be at least 25 years of age).
3. Fulfills criteria or has undergone genetic testing which confirms BRCA1, BRCA2, Familial Atypical Multiple Mole Melanoma, PeutzJeghers, HNPCC, Hereditary Pancreatitis, or ataxiatelangiectasia.
Exclusion criteria:
1. Any contraindication to MRI, including but not limited to implanted metal devices (e.g. pacemaker, berry aneurysm clips, neural stimulator or cochlear implants).
2. Known pancreatic malignancy or dysplasia.
3. Pregnancy.
4. History of sensitivity to secretin.
5. Creatinine greater than 2.
6. Unwillingness or inability to provide informed consent
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| URL: | |
| Clinical Areas: | Pancreas |
| Contact: | For more information, please contact
Joanna Martinez-Gomez, MPH
Phone: 212-305-9337
E-mail: jm2648@columbia.edu
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