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Home > Patient Guide > Clinical Trials
Clinical Trials: Detail
| Title: | MRCP with Secretin-Stimulation for the Evaluation of Pancreatic Endocrine and Exocrine Function Following Surgical Resection for Pancreatic Adenocarcinoma |
| Trial Start Date: | 5/12/2008 |
| Trial End Date: | 5/11/2009 |
| Principal Investigator: | Harold Frucht, MD |
| Description: | The aim of this study is to determine whether S-MRCP as well as traditional MRI of the pancreas, in comparison to clinical and serological markers, will allow us to quantify the pancreas' ability to secrete both hormones and digestive enzymes. In order to prevent and treat complications following pancreatic resection, doctors must accurately gauge pancreatic function both before and after surgery. However, most methods of measurement are either invasive or innacurate. A new test called secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) uses MRI technology enhanced by the use of the hormone secretin to more clearly visualize the ducts of the pancreas. S-MRCP is already known to be an accurate test to look for the amount of digestive enzymes that the pancreas is producing however, it has not been evaluated extensively in patients undergoing surgery for their cancer. |
| Criteria: | Inclusion criteria
1. 18 years of age or older
2. Tissue confirmed diagnosis of pancreatic adenocarcinoma
3. Scheduled for surgical resection (Whipple or distal pancreatectomy)
Exclusion criteria
1. Chemotherapy for pancreatic cancer prior to surgery
2. History of any radiation therapy to the abdomen prior to surgery
3. Any condition or implant which wouldn't allow the subject to undergo an MRI (e.g. pacemaker, berry aneurysm clips, neural stimulator, cochlear implants)
4. Presence of pancreatic duct stent
5. Treatment with an investigational drug within 1 month prior to the day of the study drug administration
6. Current enrollment in any other interventional study
7. Significant liver disease, liver masses, or evidence of portal hypertension
8. Pregnancy
9. History of sensitivity to secretin
10. Unwilling or unable to sign informed consent |
| URL: | |
| Clinical Areas: | Pancreas |
| Contact: | For more information, please contact
Joanna Martinez-Gomez,
Phone: 212-305-9337
E-mail: jm2648@columbia.edu
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