Purpose

This study compares outcomes of treatment for depression with two standard anti-depressant medicines that work differently in the body. Several brain tests performed prior to and after treatment at week 1 and week 12 intervals will be performed to ascertain brain differences associated with depression and to determine whether these test results change during treatment or predict treatment response.

• Type of Study: Clinical Trial
• Setting of Study: outpatient
• Clinical Trials.gov number: 
• Providing Clinical Treatment?: Yes
• No Cost Treatment?: Yes
• Care is provided in languages: English

Study Activities

• Filling Out Forms
• Computer Tasks
• Blood Samples
• Psychophysiology measurements
• Provides Payment: Compensation for study related procedures

Eligibility

• Ages Eligible for Study: 18 Years - 65 Years
• Genders Eligible for Study: Both
• This study is recruiting Healthy Volunteers.

Criteria

• Inclusion Criteria:
  Patients
  1) diagnosis of major depression, dysthymia or depression NOS
  2) 18-65 years old
  3) male or female
  
  Normal Controls
  1) 18-65 years old
  2) male or female
  
• Links
  Depression Evaluation Service website
  Columbia Department of Psychiatry
  New York State Psychiatric Institute
  
• Location: Unit 50 NYSPI 1051 Riverside Drive New York, NY 10032
• Clinic: Depression Evaluation Service
• Division: Therapeutics
• Study chairs or principal investigators: Gerard Bruder PhD, Principal Investigator
• Co-investigators: Jonathan Stewart, Craig Tenke, Jergen Kayser, Jeff Miller, Ronit Kishon