Purpose

Both refractory depression and bipolar depression are difficult to treat. A night of complete sleep deprivation has been shown to result in marked improvement in 60% of depressed patients, although maintenance of therapeutic effects have not been sustained with wake therapy alone. This pilot study will assess the effectiveness of wake therapy in treating both bipolar depression (5 participants)and major depression (5 participants), as well as the effectiveness of additional light therapy and lithium in mantaining the therapeutic effects. Participants will undergo direct observation in the hospital for one week during initial treatment, and then will be seen weekly as outpatients for 6 weeks.

• Type of Study: Clinical Trial
• Setting of Study: both
• Clinical Trials.gov number: NCT01431573
• Providing Clinical Treatment?: Yes
• No Cost Treatment?: Yes
• Care is provided in languages: English

Study Activities

• Filling Out Forms
• Computer Tasks
• Blood Samples

Eligibility

• Ages Eligible for Study: 18 Years - 60 Years
• Genders Eligible for Study: Both
• This study is not recruiting Healthy Volunteers.

Criteria

• Inclusion Criteria:
  1. current major depressive episode(MDD, BP-I or BP-II)
  2. if not BP-I or BP-II, treatment refractory to ≥ 2 adequately used antidepressants having different mechanisms
  3. If BP-I or BP-II, treatment refractory to ≥ 1 standard treatment, such as lithium or valproate
  4. physically healthy
  5. age 18-60
  6. not taking current antidepressants(antidepressants deemed effective will not be discontinued
  
• Links
  Depression Evaluation Service
  Columbia Psychiatry
  New York State Psychiatric Institute
  
• Location: Box 51 1051 Riverside Drive New York, NY 10032
• Clinic: Depression Evaluation Service
• Division: Therapeutics
• Study chairs or principal investigators: Jonathan W. Stewart M.D., Principal Investigator
• Co-investigators: Michael Terman, Patrick McGrath,