Purpose

This is a research study of women’s experiences during and after breast cancer treatment. The purpose of this study is to understand better whether chemotherapy and estrogen level affect thinking processes such as memory and attention, anxious and depressed mood, sleep quality, or fatigue. This information will be used to understand better the effects of chemotherapy treatment among women with breast cancer. We are recruiting women ages 21-50 who meet the following criteria: diagnosis of and curative surgery for early-stage breast cancer (Stage I to III)to be followed by chemotherapy; OR women who have been diagnosed with benign breast disease (such as fibroadenoma or atypical ductal hyperplasia) and have undergone curative surgery but will not be receiving chemotherapy treatment; OR women who have not been diagnosed with any cancer.

Type of Study: Observational Type
Setting of Study: outpatient
Clinical Trials.gov number: 
Providing Clinical Treatment?: No
Care is provided in languages: English

Study Activities

Filling Out Forms
Computer Tasks
Blood Samples
MRI Scan
Provides Payment: Compensation for study related procedures

Eligibility

Ages Eligible for Study: 21 Years - 50 Years
Genders Eligible for Study: Female
This study is recruiting Healthy Volunteers.

Criteria

Inclusion Criteria:
Experimental Group
1. Women between the ages of 21-50.
2. Premenopausal: regular periods for prior 12 months or follicle stimulating hormone level < 30 (FSH)
3. Undergoing curative breast cancer surgery (mastectomy or lumpectomy).
4. Scheduled to receive but not yet begun 3 to 6 months of adjuvant chemotherapy.
5. Minimal reading and speaking fluency in English (Grade 5 level).

Benign Breast Disease Group
1. Women between the ages of 21-50.
2. Premenopausal: regular periods for prior 12 months or follicle stimulating hormone level < 30 (FSH)
3. Undergoing curative breast cancer surgery (mastectomy or lumpectomy).
4. Minimal reading and speaking fluency in English (Grade 5 level).

Healthy Control Group
1. Women between the ages of 21-50.
2. Premenopausal: regular periods for prior 12 months or follicle stimulating hormone level < 30 (FSH)
3. Minimal reading and speaking fluency in English (Grade 5 level).

Location: Columbia University Medical Center Behavioral Medicine Berrie Building 1150 St. Nicholas Avenue, Suite 1-121 New York, NY 10032
Clinic: 
Division: Behavioral Medicine

Study chairs or principal investigators:
Felice Tager Ph.D., Principal Investigator

Co-investigators:
Paula S. McKinley, Ph.D.,