Purpose

Participating adolescent and two family members will be evaluated for psychiatric disorders, suicide attempt history, tendency for impulsive aggression, and life events. This interview lasts approximately 4 hours, which can be completed over several visits. In addition, all family members will be asked to give a blood sample or saliva sample for DNA research. All of the interviews will be provided at no cost. Because families will not benefit directly from the study, every participating family member will be compensated for their participation.

Type of Study: Observational Type
Setting of Study: both
Clinical Trials.gov number: 
Providing Clinical Treatment?: No
Care is provided in languages: English

Study Activities

Filling Out Forms
Blood Samples
Blood Samples for DNA
Psychophysiology measurements
Provides Payment: Reimbursement for transportation
Provides Payment: Compensation for study related procedures

Eligibility

Ages Eligible for Study: 12 Years - 19 Years
Genders Eligible for Study: Both
This study is not recruiting Healthy Volunteers.

Criteria

Inclusion Criteria:
1. Subject must be 12 to 19 years old (inclusive), any gender
2. Subject must have a lifetime history of at least one suicide attempt
3. Subject must have current or lifetime history of a Major Depressive Episode. (Major Depressive Episode may be in the context of either a Major Depressive Disorder or Bipolar Disorder)
4. Subject must have two first-degree biological family members--either 2 parents, or 1 parent and 1 full sibling at least 10 years old--who are willing to participate
5. All particpants must speak English

Location: New York State Psychiatric Institute 1051 Riverside Drive, Unit 74 New York, NY 10032
Clinic: Neuroscience Clinic for Mood and Personality Disorders
Division: Child Psychiatry

Study chairs or principal investigators:
Laurence L. Greenhill M.D., Principal Investigator

Co-investigators:
John Mann,
Gil Zalsman,
Maria Oquendo,
Jane Fried,
David Shaffer