Purpose

This study will evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of Panic Disorder and Major Depression for patients who have not fully responded to conventional therapies. rTMS is a non-invasive procedure that allows stimulation of the brain using magnetic fields.

Type of Study: Clinical Trial
Setting of Study: outpatient
Clinical Trials.gov number: NCT00521352
Providing Clinical Treatment?: Yes
No Cost Treatment?: Yes
Care is provided in languages: English

Study Activities

Filling Out Forms
Blood Samples
Psychophysiology measurements

Eligibility

Ages Eligible for Study: 18 Years - 65 Years
Genders Eligible for Study: Both
This study is not recruiting Healthy Volunteers.

Criteria

Inclusion Criteria:
Inclusion Criteria:

* Patients with a primary diagnosis of Panic Disorder and Major Depressive Disorder, as confirmed by the Structured Clinical Interview for the DSM-IV-TR (SCID); residual panic attacks and MDD symptoms, defined as a total PDSS score of ≥20 and HDRS-17 score ≥18, despite treatment with an adequate trial of a serotonin reuptake inhibitor (SRI); and a duration of the index episode of at least a month will be included. An adequate SRI trial is defined as treatment for at least 6-8 weeks on the SRI, that meets the maximum recommended dosage level for PD and MDD (fluoxetine 40-60 mg/d, sertraline 100-200 mg/d, paroxetine 40-60 mg/d, fluvoxamine 200-300 mg/d, citalopram 40-60 mg/d, escitalopram 20-30 mg/d).
* Individuals who cannot tolerate medications of class and dose at the specified duration as described above will also be included.
* Patients currently on medication must be at the same stable dose(s) for one month prior to enrollment and be willing to continue at the same dose(s) through the duration of the study.


Links
Division of Brain Stimulation and Therapeutic Modulation home page
Study summary on Division of Brain Stimulation and Therapeutic Modulation web site

Location: 1051 Riverside Drive, Unit 21 New York, NY 10032
Clinic: Novel Treatments for Depression Service
Division: Other

Study chairs or principal investigators:
Antonio Mantovani MD, PhD, Principal Investigator

Co-investigators:
Sarah H. Lisanby, MD,
Helen B. Simpson, MD, PhD,
Alexandra Sporn, MD,
Peter M. Bulow, MD,