Purpose

Standard listening tests where different sounds are presented to each ear as a measure of brain function have shown that differences in left and right brain processing of sound in depressed patients is also associated with differences in response to treatment. This study will assess this phenomenon under new treatment conditions. In this study, 100 depressed patients will be treated sequentially with the widely used antidepressant medications, Wellbutrin, Lexapro, and Tofranil (generic name imipramine), after completing listening tests. The results will show whether preferential brain processing for sounds is associated with treatment outcome.

Type of Study: Clinical Trial
Setting of Study: outpatient
Clinical Trials.gov number: NCT00404755
Providing Clinical Treatment?: Yes
No Cost Treatment?: Yes

Study Activities

Filling Out Forms
Blood Samples
Psychophysiology measurements

Eligibility

Ages Eligible for Study: 18 Years - 65 Years
Genders Eligible for Study: Both
This study is not recruiting Healthy Volunteers.

Criteria

Inclusion Criteria:
Inclusion Criteria:
1. Ages between 18-65
2. Meets DSM-IV criteria for current Major Depression, Dysthymia or Depression NOS



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Links
Official website of the Depression Evaluation Service of the New York State Psychiatric Institute

Location: Unit 51 New York State Psychiatric Institute 1051 Riverside Drive New York, NY 10032
Clinic: Depression Evaluation Service
Division: Therapeutics

Study chairs or principal investigators:
Jonathan W. Stewart M.D., Principal Investigator

Co-investigators:
Gerard Bruder,