Purpose

This 5-year longitudinal study will use functional MRI to better understand brain structure and function in persons who have been diagnosed with Bipolar Disorder (BD), particularly during changes in mood states (i.e., switching from normal mood to manic). Participation will include multiple MRI scans, neuropsychological testing, and diagnostic interviews. All participants will come in for a baseline study visit (MRI, neuropsych, interviews) and a visit at the end of the study period (MRI, interviews). We will also make monthly follow up calls during which we will administer three short measures of affective state. If during these calls we determine a participant has undergone a state-switch, we will invite him/her to come in for another MRI and set of interviews. Participants may be asked to come in for as many as 4-5 scans over the course of the study.

Type of Study: Other Study Type
Setting of Study: outpatient
Clinical Trials.gov number: 
Providing Clinical Treatment?: No

Study Activities

Filling Out Forms
Computer Tasks
MRI Scan

Eligibility

Ages Eligible for Study: 15 Years - 35 Years
Genders Eligible for Study: Both
This study is recruiting Healthy Volunteers.

Criteria

Inclusion Criteria:
1. Age 15-35 years
2. Prior diagnosis of early onset Bipolar Disorder (including those who are acutely manic or acutely depressed)
3. All subjects must have a treating clinician who can provide appropriate psychiatric care

Location: Kristin Werner New York State Psychiatric Institute 1051 Riverside Drive, Unit 74 New York, NY 10032
Clinic: 
Division: Child Psychiatry

Study chairs or principal investigators:
Bradley S Peterson MD, Principal Investigator

Co-investigators:
Jose Amat,
Dongrong Xu,
Ann Marcotte,
Andrew Gerber,
Tiziano Colibazzi