Purpose

The purpose of the study is to compare the medication venlafaxine (Effexor XR) to placebo in the treatment of symptoms of depression in patients who also have difficulties with memory or other intellectual abilities. The study has three parts. First, in a twelve-week study, the effectiveness and safety of Effexor XR and placebo in the treatment of depression will be compared, and the patient’s intellectual difficulties will be assessed for any changes. Second, after the twelve-week study, the patient will receive non-study treatment at no cost for a minimum of three months. Third, after this minimum three-month period of open treatment, the patient will return for a follow-up visit every six months for an additional two and a half years.

Type of Study: Clinical Trial
Setting of Study: 
Clinical Trials.gov number: 
Providing Clinical Treatment?: Yes
No Cost Treatment?: Yes

Study Activities

Eligibility

Ages Eligible for Study: Years - Years
Genders Eligible for Study: 
This study is not recruiting Healthy Volunteers.

Criteria

Inclusion Criteria:

Location: NYSPI Unit 126 1051 Riverside Dr. New York, NY 10032
Clinic: Mid and Late Life Depression
Division: Biological Psychiatry

Study chairs or principal investigators:
Gregory H. Pelton M.D., Principal Investigator

Co-investigators:
D.P. Devanand,
Harold Sackeim,