Research Faculty

Address
630 West 168th Street,
VC 14-236
New York NY 10032

Phone: 646-317-4785
Fax:

rjl2165@cumc.columbia.com
Rebecca J. Leeman-Neill, M.D., Ph.D.
Assistant Professor of Pathology and Cell Biology at the Columbia University Medical Center
Research Summary

My current research focuses on characterization of molecular alterations that play a role in B cell lymphomagenesis, specifically in diffuse large B cell lymphoma.

I have a background in environmental exposure-related neoplasia (pesticide exposure-related lymphomagenesis, radiation-related thyroid carcinogenesis, and carcinogen-related head and neck carcinogenesis) as well as in chemoprevention of head and neck cancer.


Affiliation
Hematopathology
Service Activities

Diagnostic Hematopathology
Selected Publications

Gibson, SE, Leeman-Neill, RJ, Jain, S, Piao, W, Cieply, KM, Swerdlow, SH. “Proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma have enhanced expression of MYC protein, which does not result from rearrangement or gain of the MYC gene.” Br. J. Hematol 2016 Oct; 175(1):173-5.

Johnson, WT, Leeman-Neill, RJ, Patel, P, Ho, J, Grandinetti, L, Craig, FE, and Jedrych, J. “A Fatal Case of Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell lymphoma Initially Presenting with a CD4+ Phenotype: Progressive disease with Bexarotene and Romidepsin,” Am. J. Dermatopathol 2016 Nov; 38(11):832-837.

Bogdanova, TI, Zurnadzhy, LY, Nikiforov, YE, Leeman-Neill, RJ, Tronko, MD, Chanock, S, Mabuchi, K, Likhtarov, IA, Kovgan, LM, Drozdovitch, V, Little, MP, Hatch, M, Zablotska, LB, Shpak, VM, McConnell, RJ, Brenner, AV. “Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort.” Br. J. Cancer 2015 Dec; 113(11):1556-64.

Leeman-Neill, R.J., Kelly, L.M., Liu, P., Brenner, A.V., Little, M.P., Bogdanova, T.I., Evdokimova, V.N., Hatch, M., Zurnadzy, L.Y., Nikiforova, M.N., Yue, N.J., Zhang, M., Mabuchi, K., Tronko, M.D., Nikiforov, Y.E. “ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid cancer.” Cancer 2014 March; 120(6):799-807.

Leeman-Neill, R.J., Brenner, A.V., Little, M.P., Bogdanova, T.I., Maureen, H., Zurnadzy, L.Y., Mabuchi, K., Tronko, M.D., Nikiforov, Y.E. "RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with I-131 radiation dose and other characteristics." Cancer 2013 May; 119(10): 1792-9

Leeman-Neill, R.J., Seethala, R.R., Singh, S.V., Freilino, M.L., Bednash, J.S., Thomas, S.M., Panahandeh, M.C., Gooding, W.E., Joyce, S.C., Lingen, M.W., Neill, D.B., and Grandis, J.R. “Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma” Cancer Prev Res 2011 Feb; 4(2): 230-7

Wheeler, S.E., Suzuki, S., Thomas, S.M., Leeman-Neill, R.J., Chiosea, S.I., Kuan, C.T., Bigner, D.D., Gooding, W.E., Lai, S.Y., and Grandis, J.R. “Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation” Oncogene 2010 Sep; 29(37): 5135-45

Leeman-Neill, R.J., Cai, Q., Joyce, S.C., Thomas, S.M., Bhola, N.E., Neill, D.B., Arbiser, J.L., and Grandis, J.R. “Honokiol inhibits EGFR signaling and enhances antitumor effects of EGFR inhibitors” Clin Cancer Res 2010 May; 16(9): 2571-9 4

Leeman-Neill, R.J., Wheeler, S.E., Singh, S.V., Thomas, S.M., Seethala, R.R., Neill, D.B., Panahandeh, M.C., Hahm, E., Joyce, S.C., Sen, M., Cai, Q., Li, C., Johnson, D.E., and Grandis, J.R. “Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3” Carcinogenesis 2009 Nov; 30(11): 1848-56.

Li, C., Sen, M., Leeman-Neill, R.J., Man, D.S., Grandis, J.R., and Johnson, D.E., “Bortezomib upregulates activated STAT3 and synergizes with inhibitors of STAT3 to promote head and neck squamous cell carcinoma cell death” Mol. Cancer Ther. 2009 Aug; 8(8): 2211-20

Lui, V.W., Boehm, A., Koppikar, P., Leeman, R.J., Johnson, D., Ogagan, M., Childs, E., Freilino, M., Grandis, J.R., “Antiproliferative mechanisms of a transcription factor decoy targeting STAT3: the role of STAT1,” Molec. Pharm. 2007 May; 71(5): 1435-43

Leeman, R.J., Lui, V.W., Grandis, J.R. “STAT3 as a therapeutic target in head and neck cancer.” Expert Opin Biol Ther. 2006 Mar; 6(3):231-41.

Honors and Awards

2010 Robert E. Lee, MD Award for Excellence in Anatomic Pathology, University of Pittsburgh School of Medicine

2007 AACR-Women in Cancer Research Brigid G. Leventhal Scholar in Cancer Research Travel Award to AACR Frontiers in Cancer Prevention Research

2007 American Society for Clinical Pathology Award for Academic Excellence and Achievement

2006 Scholar-in-Training Travel Award to AACR Frontiers in Cancer Prevention Research

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