Research Faculty

Address
630 W 168th Street
VC 15-207
New York, NY 10032

Phone: 212-305-2155
Fax: 212-927-9704

bh2179@cumc.columbia.edu
Education and Training
MD, 2000, Westfaelische Wilhelms University Muenster, Germany

Dr. med., 2001, Westfaelische Wilhelms University Muenster, Germany

Board Certification
American Board of Pathology (2008)
American Board of Dermatopathology (2009)

Licensure
NY State medical license
CA medical license
Approbation als Arzt (German medical license)

Affiliations
Anatomy & Cell Biology
Dermatology
Herbert Irving Center

Training Activities
Resident in Dermatology and Plastic Surgery, 2001-2003, University Muenster, Germany
Postdoctoral Research Fellow in Dermatology, 2003-2005, Stanford University School of Medicine, Stan
Resident in Pathology, 2005-2008, New York Presbyterian Hospital, Columbia University Medical Center
Fellow in Dermatopathology, 2008-2009, David Geffen School of Medicine at UCLA, Los Angeles, CA
Basil Horst, MD, Dr. med.
Assistant Professor of Dermatology and Pathology and Cell Biology
Research Summary

My research focuses on mechanisms of melanoma formation and metastasis. Recent studies in my laboratory identified the phosphatase INPP4B as a melanoma tumor suppressor. These studies demonstrated for the first time that INPP4B antagonizes PI3K signaling in subsets of melanocytic cells. In translational studies we aim to define subtypes of melanocytic tumors on the molecular level. Furthermore, I am involved in collaborative studies to explore apoptotic responses in melanoma cells with the goal to potentiate efficacy of FDA-approved agents, and to optimize multi-chromatic immuno-fluorescent staining for quantitative assessment of immune infiltrates in melanoma tissue. These studies aim to improve diagnosis, outcome prediction and therapy of melanoma.
Service Activities

Sign-out of Dermatopathology Cases

Teaching of Pathology and Dermatology Residents
Selected Publications

Yang HM, Hsiao SJ, Schaeffer DF, Lai C, Remotti H, Horst D, Mansukhani M, Horst BA. Identification of Recurrent Mutational Events in Anorectal Melanoma. Mod Pathol. 2016 (In Press)

Karpel-Massler G, Horst BA, Shu C, Chau L, Tsujiuchi T, Bruce JN, Canoll P, Greene LA, Angelastro JM, Siegelin MD. A synthetic cell-penetrating dominant-negative ATF5 peptide exerts anti-cancer activity against a broad spectrum of treatment resistant cancers. Clin Cancer Res. 2016 Sep; 22(18):4698-711.

De Moll EH; Fu Y; Qian Y; Perkins SH; Wieder S; Gnjatic S; Remark R; Bernardo SG; Moskalenko M; Yao J; Ferringer T; Chang R; Chipuk J; Horst BA; Birge MB; Phelps RG; Saenger YM. Immune biomarkers are more accurate in prediction of survival in ulcerated than in non-ulcerated primary melanomas. Cancer Immunol Immunother. 2015 Sep;64(9):1193-203. [PMCID: PMC4581435]

Perez-Lorenzo R, Gill KZ, Shen C, Zhao FX, Zheng B, Schulze HJ, Silvers DN, Brunner G, Horst BA. A Tumor Suppressor Function for the Lipid Phosphatase INPP4B in Melanocytic Neoplasms. J Invest Dermatol. 2014 May;134(5):1359-68.

Horst BA, Terrano D, Fang Y, Silvers DN, Busam KJ. 9p21 Gene Locus in Spitz Nevi of Older Individuals: Absence of Cytogenetic and Immunohistochemical Findings Associated With Malignancy. Hum Pathol. 2013 Dec;44(12):2822-8.

Horst B, Gruvberger-Saal SK, Hopkins BD, Bordone L, Yang Y, Chernoff KA, Uzoma I, Schwipper V, Liebau J, Nowak NJ, Brunner G, Owens D, Rimm DL, Parsons R, Celebi JT. Gab2-mediated signaling promotes melanoma metastasis. Am J Pathol. 2009 Apr;174(4):1524-33. [PMID: 19342374] [PMCID: PMC2671382]

Honors and Awards

2005 Dean's Fellowship Award, Stanford University, Stanford, CA

2012 Dermatopathology Research Career Development Award, Dermatology Foundation

2013 Dermatopathology Research Career Development Award, Dermatology Foundation

2013 Teacher of the Year 2012-2013, Columbia University Department of Dermatology

2014 Dermatopathology Research Career Development Award, Dermatology Foundation
Committees , Council, and Professional Society Memberships

College of American Pathologists
American Society of Dermatopathology
Herbert Irving Comprehensive Cancer Center, Program Cancer Regulatory Networks
Keywords

Melanoma


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