I am interested in the genetic pathways that lead to carcinogenesis in the digestive tract. FLI1, a transcription factor with a tumorigenic role in Ewing’s sarcoma, has been shown to be downregulated in gastric cancers, suggesting a possible tumor suppressor role. My current research is investigating the role of FLI1 in gastric adenocarcinomas by analyzing both primary human tumors and established gastric cancer cell lines.
Ravi K. Amaravadi, Kathryn E. Hamilton, Xiaohong Ma, Shengfu Piao, Armando Del Portillo
, Katherine L. Nathanson, Matteo S. Carlino, Georgina V. Long, Igor Puzanov, Xiaowei Xu, Jennifer J.D. Morrissette, Kenneth Y. Tsai, Keith T. Flaherty, Jeffrey A. Sosman, Grant R. Goodman, Grant A. McArthur, Anil K. Rustgi, David C. Metz, Lynn M. Schuchter, Paul B. Chapman, Antonia R. Sepulveda. “Multiple gastrointestinal polyps in patients treated with BRAF inhibitors.” Clinical Cancer Research
, Dec 2015;21(23):5215-21.Armando Del Portillo
, Stephen M Lagana, Yuan Yao, Takeshi Uehara, Nirag Jhala, Tapan Ganguly, Peter Nagy, Jorge Gutierrez, Aesis Luna, Julian Abrams, Yang Liu, Randall Brand, Jorge Sepulveda, Gary Falk, Antonia R Sepulveda. “Evaluation of Mutational Testing of Pre-neoplastic Barrett’s Mucosa by Next Generation Sequencing of FFPE Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett’s Esophagus.” Journal of Molecular Diagnostics
, Jul 2015;17(4):412-9.