Research Faculty

Address
1130 St. Nicholas Ave.,
Room 814,
New York, NY 10032

Phone: 212-851-4654
Fax: 212-851-4650

tg2310@cumc.columbia.edu
Education and Training
MD. PhD., Mount Sinai School of Medicine

Residency in Clinical Pathology, Columbia University Medical Center/New York Presbyterian Hospital

Fellowship in Hematopathology, Columbia University Medical Center/New York Presbyterian Hospital

Research Fellowship, Center for Computational Biology and Bioinformatics, Columbia University Medical Center

Tatyana Gindin, M.D., Ph.D.
Assistant Professor of Pathology and Cell Biology
Research Summary

My research interests are primarily concerned with the development and use of theoretical biophysical and bioinformatics methodology to study the structural and energetic origins of protein-protein and protein-peptide interactions. Specific applications include exploration of origins of specificity of antibody-antigen and MHC-peptide interactions with long term goals of antibody improvement and HIV-1 vaccine development.
Service Activities

Molecular Pathology
Selected Publications

Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS; NISC Comparative Sequencing Program, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP Jr, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell. 2015 Jun 4;161(6):1280-92.

Gindin T, Murty V, Alobeid B, Bhagat G. MLL/KMT2A translocations in diffuse large B-cell lymphomas. Hematol Oncol. 2015 Dec;33(4)239-46

Cai CX, Siringo FS, Odel JG, Lignelli-Dipple A, Lanzman B, Gindin T, Filipovich AH. Downbeat Nystagmus Secondary to Familial Hemophagocytic Lymphohistiocytosis.
J. Neuroopthalmol. 2014 Mar;34(1):57-60

Mikles B, Levine J, Gindin T, Bhagat G, Satwani P. Brentuximab Vedotin (SGN-35) in a 3-year-old child with relapsed systemic anaplastic large cell lymphoma. J Pediatr Hematol Oncol. 2014 Mar;36(2):e85-7

Fang Y, Pinkney KA, Lee JC, Gindin T, Weiner MA, Alobeid B, Bhagat G. T-cell acute lymphoblastic leukaemia after liver transplantation: post-transplant lymphoproliferative disorder or coincidental de novo leukaemia? Hematol Oncol. 2013 Mar;31(1):49-53

Alex Kentsis, Tatyana Gindin, Mihaly Mezei, Roman Osman. Calculation of the free energy and cooperativity of protein folding. PLoS ONE. 2007 May 16;2:e446.

Kentsis A, Mezei M, Gindin T, Osman R. Unfolded state of polyproline is a segmented polyproline II helix. Proteins. 2004 May 15;55(3):493-501.

Gindin T, Seibert E, Rachofsky E, Hawkins M, Ross J, Osman R. Computations of fluorescence properties of nucleotide analogues in DNA. Biophys. J. 2002: 82(1):485

Current Projects

- Characterization of structural determinants of HIV gp120 recognition by broadly neutralizing antibodies

- Exploring molecular mechanisms of specificity of MHC-peptide interactions


Committees , Council, and Professional Society Memberships

USCAP, ASCP, Society of Hematopathology

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