Research Faculty

Address
630W 168th Street
P&S 12-420C
New York 10032 NY

Phone: 212-304-5500
Fax: 212-342-0119

sah2149@cumc.columbia.edu

Collaborations
Karen Duff, Eric Kandel, Steve Siegelbaum,
Gil Di Paolo. Elisa Konofagou

Affiliations
Neurobiology & Behavior
Taub Institute

Abid Hussaini, Ph.D.
Assistant Professor of Neurobiology (in Pathology and Cell Biology and the Taub Institute)
Research Summary

My lab is interested in the neurobiology of Alzheimer's disease. The aim is to understand the neural correlates of cognitive dysfunction by studying regions of the brain that are most vulnerable to the disease. The entorhinal cortex-hippocampal (EC-HPC) circuit is a major network hub for memory and its neurons are among the first to be affected leading to impaired memory. My lab is using in vivo electrophysiology and optogenetic techniques in mice to study the neuronal (dys)function in the EC-HPC circuit. In collaboration with Dr Karen Duff the lab is using novel mouse models of Alzheimer's disease that closely mimic pathologies and cognitive impairments seen in humans. The overarching goal of the lab is to be able to detect dysfunction in earlier stages of the disease and to restore cognitive function by manipulating neurons with optogenetic stimulation or deep brain stimulation.
Selected Publications

Hussaini SA, Kempadoo AK, Thuault SJ, Siegelbaum SA and Kandel ER. Increased Size and Stability of CA1 and CA3 Place Fields in HCN1 Knockout Mice. Neuron. Volume 72, Issue 4, 643-653, 2011.

Giocomo LM, Hussaini SA, Zheng F, Kandel ER, Moser MB and Moser EI, Grid Cells Use HCN1 Channels for Spatial Scaling. Cell. Volume 147, Issue 5, 1159-1170, 2011.

Hussaini SA, Menzel R, Mushroom Body Extrinsic Neurons in the Honeybee Brain Encode Cues and Contexts Differently. J. Neurosci. 24;33(17):7154-64. 2013

Current Projects

Hippocampal and entorhinal cortex dysfunction in AD mice.

Honors and Awards

Alzheimer’s association award.
Committees , Council, and Professional Society Memberships

Society for Neuroscience, Alzheimer’s association, New York Academy of Sciences
Keywords

Neurodegeneration, Alzheimer’s disease, Aging, Electrophysiology, Optogenetics, Hippocampus, Entorhinal cortex, Place cells, Grid cells, Spatial navigation, Learning and memory


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