Research Faculty

Address
1130 St. Nicholas Av. Rm 506
New York, NY 10032

Phone: 212-8514786
Fax: 212-8515256

kb451@cumc.columbia.edu
Katia Basso, Ph.D.
Assistant Professor of Pathology & Cell Biology in the Institute for Cancer Genetics
Research Summary

The overall focus of my research activity is to elucidate the pathogenesis of mature B cell lymphomas that originate from the malignant transformation of germinal center B cells. Toward this goal, I aim to the identification and functional characterization of critical players in B cell development and lymphomagenesis by integrating computational and biochemical approaches.
Selected Publications

Dominguez-Sola, D., Kung, J., Holmes, A.B., Wells, V.A., Mo, T., Basso, K., Dalla-Favera, R.: “The FOXO1 transcription factor instructs the germinal center dark zone program”. Immunity 43(6):1064-74 (2015).

Basso, K. and Dalla-Favera R.: “Germinal centres and B cell lymphomagenesis”. Nat Rev Immunol. 15(3):172-84 (2015).

Schneider, C., Setty, M., Holmes, A.B., Maute, R.L., Leslie, C.S., Mussolin, L., Rosolen, A., Dalla-Favera, R., Basso, K.: “microRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas”. Proc. Natl. Acad. Sci. USA 111(22):8185-90 (2014).

Maute, R.L., Dalla-Favera R. and Basso, K.: “RNA with multiple personalities”. Wiley Interdiscip Rev RNA 5(1):1-13 (2014).

Ying, C.Y., Dominguez-Sola, D., Fabi, M., Lorenz, I.C., Hussein, S., Bansal, M., Califano, A., Pasqualucci, L., Basso, K., Dalla-Favera, R.: “MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma”. Nat Immunol. 14(10):1084-92 (2013).

Maute, R.L., Schneider, C., Sumazin, P., Holmes, A., Califano, A., Basso, K.* and Dalla-Favera R.*: “t-RNA-derived microRNA modulates proliferation and DNA damage response and is down-regulated in B cell lymphoma”. Proc. Natl. Acad. Sci. USA 110(4):1404-9 (2013). [*equal contribution]

Basso, K., Schneider, C., Shen, Q., Holmes, A.B., Setty, M., Leslie, C., Dalla-Favera R.: “BCL6 positevely regulates AID and germinal center gene expression via repression of miR-155”. J. Exp. Med. 247(1): 172-83 (2012).

Basso, K., Saito, M., Sumazin, P., Margolin, A.A., Wang, K., Lim, W-K., Kitagawa, Y., Schneider, C., Alvarez, M., Califano, A., Dalla-Favera, R.: “Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal-center B cells”. Blood 115(5):975-84 (2010).

Basso, K., Sumazin, P., Morozov, P., Schneider, C., Maute, R.L., Kitagawa, Y., Mandelbaum, J., Haddad J., Chen C.Z., Califano, A., Dalla-Favera, R.: “Identification of the human mature B cell miRNome”. Immunity. 30(5): 744-52 (2009).

Basso, K., Margolin, A.A., Stolovitzky, G., Klein, U., Dalla-Favera, R. and Califano, A.: “Reverse engineering of regulatory networks in human B cells”. Nat Genet. 37(4): 382-90 (2005).


top
 
 
Contact the Pathology Webmaster at PathWebMaster@columbia.edu