I am the founding Director of the Stem Cell and Cellular Models Platform at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, a core facility that was established with the goal to implement pluripotent stem cell technology as a resource for neurodegenerative and neurological disease researchers at Columbia University. Our laboratory’s main focus is developing robust differentiation protocols for large-scale production of disease-relevant neurons and other CNS cell types, and using gene-editing strategies to create allelic series of isogenic disease and control pluripotent stem cell (PSC) lines. These tools will greatly aid mechanistic studies of disease mechanisms and provide a better platform for therapeutic screening. In addition to partnering with a variety of Taub investigators on disease-related research, our laboratory is interested in elucidating novel mechanistic links between aberrant APP processing and Tau dysregulation.
. (2015) Being human: The role of pluripotent stem cells in regenerative medicine and humanizing Alzheimer's disease models. Mol Aspects Med
. 43-44:54-65. doi: 10.1016/j.mam.2015.06.007. PMID: 26101165.
Prè D, Nestor MW, Sproul, AA
, Jacob S, Koppensteiner P, Chinchalongporn V, Zimmer M, Yamamoto A, Noggle SA, Arancio O. (2014) A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs). PLoS One
. 9:e103418. PMID: 25072157Sproul, AA
, Jacob S, Pre D, Kim, SH, Nestor MW, Navarro-Sobrino, M, Santa Maria, I, Zimmer, M, Aubrey S, Steele MW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, Noggle SA. (2014) Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors. PLoS ONE
9, e84547. PMID: 24416243.Sproul, AA
, Vensand LB, Dusenberry CR, Jacob S, Vonsattel JP, Paull DJ, Shelanski ML, Crary Noggle SA. (2014) Generation of iPSC lines from archived non-cryoprotected biobanked dura mater. Acta Neuropathol Commun
2, 4. PMID: 24398250.
Nestor MW, Paull D, Jacob S, Sproul, AA
, Alsaffar A, Campos BA, Noggle SA. (2013) Differentiation of serum-free embryoid bodies from human induced pluripotent stem cells into networks. Stem Cell Res
.10(3):454-63. PMID: 23500645.
For a complete list of my publications, please click the button below:
pluripotent stem cells, neuronal differentiation, genome-editing, Alzheimer’s disease