- Translational studies to develop novel molecular risk assessment strategies, and to improve therapies for oral squamous cell carcinoma.
- Clinical trials, both investigator-initiated and multi-centered, to evaluate the efficacy of chemopreventive agents of oral cancer.
, Shen J, Santella RM, Zegarelli DJ, Chen R, Weinstein IB. Activated checkpoint kinase 2 expression and risk for oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2007;1:2768-2772 (NIHMSID # 70903).
, Shen J, Wu H, Angelopoulos D, Singer S, Chen R, Santella RM. Expression of Checkpoint Kinase 2 and Histone 2AX in Exfoliative Oral Cells Following Exposure to Ionizing Radiation. Radiat. Res. 2009;171:771-775 (NIHMSID # 439211).
Zavras AI, Yoon AJ
, Chen MK, Lin CW, Yang SF. Metallothionein-1 genotypes in the risk of oral squamous cell carcinoma. Ann Surg Oncol. 2011;18:1473-1483.Yoon AJ
, Kuo WH, Lin CW, Yang SF. Role of ERCC5 polymorphism in risk of hepatocellular carcinoma. Oncol Letters. 2011;2:911-914.Yoon AJ
, Zavras AI, Chen MK, Lin CW, Yang SF. Association between Gly1619ARG polymorphism of IGF2R domain 11 (RS629849) and advanced stage of oral cancer. Med Oncol 2012;29:682-685.Yoon AJ
, Cheng B, Philipone E, Turner R, Lamster IB. Inflammatory biomarkers in saliva: assessing the contribution of diabetes mellitus and periodontal status to the oral inflammatory burden. J Clin Periodontol 2012;39:434-440.
, Shen J, Santella RM, Philipone EM, Wu HC, Eisig SB, Blitzer A, Close LG, Zegarelli DJ. Topical application of green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) for prevention of recurrent oral neoplastic lesions. JOFS 2012;4:43-50 (NIHMSID # 439216).
Zavras AI, Yoon AJ
, Chen MK, Lin CW, Yang SF. Association between polymorphisms of DNA repair gene ERCC5 and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2012;114:624-629.
, Wang S, Shen J, Robine N, Philipone E, Oster M, Nam A, Santella RM. Prognostic value of miR-375 and miR-214-3p in early stage oral squamous cell carcinoma. Am J Transl Res 2014;6:580-592.
Assessing the prognostic utility of microRNA-based markers for oral cancer patients. This study aims to create a point-of-care clinical application of individualized microRNA profiles in oral cancer prognostication and treatment selection guidance.
Honors and Awards
7/2015 - Interdisciplinary appointment in the Department of Pathology and Cell Biology at the Columbia University Medical Center
5/2013 - The Edward V Zegarelli Teaching Award, CU CDM
Committees , Council, and Professional Society Memberships
• American Association for Cancer Research
• American Academy of Oral and Maxillofacial Pathology
• The American Academy of Oral Medicine
• United States and Canadian Academy of Pathology
• American Dental Association
• Omicron Kappa Upsilon Fraternity
Oral lesions, epithelial dysplasia, oral squamous cell carcinoma, prognostic biomarkers, microRNA