My research focuses on the metabolic profiles of patients with inherited and acquired diseases with the goal of discovering novel biomarkers for disease diagnoses as well as monitoring disease progression using high throughput/high sensitivity mass spectrometry based assays.
, Petrie K, Shim J, Abildskov KM, Westhoff CL, Cremers S. A UPLC-MS/MS Method for Therapeutic Drug Monitoring of Etonogestrel. Therapeutic Drug Monitoring. Ther Drug Monit. 2013 Dec;35(6):844-8.
Zhou H, Castro-Perez J, Lassman M, Thomas T
, Li W, McLaughlin T, Xie D, Jumes P, Wagner JA, Gutstein DE, Hubbard BK, Rader DJ, Millar JS, Ginsberg H, Reyes-Soffer G, Cleary M, Previs SF, Roddy T. Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry. Rapid Communications in Mass Spectrometr. Rapid Commun Mass Spectrom. 2013 Jun 30;27(12):1294-302.Thomas T
, Broun EC, Abildskov KM, Kubin CJ, Horan J, Yin MT, Cremers S. High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma. Ther Drug Monit. 2012 Aug;34(4):398-405.
Dragoman M, Petrie K, Torgal A, Thomas T
, Cremers S, Westhoff CL. Contraceptive vaginal ring effectiveness is maintained during 6 weeks of use: a prospective study of normal BMI and obese women. Contraception. 2013, In Press.
Westhoff CL, Torgal AH, Mayeda ER, Petrie K, Thomas T
, Dragoman MV, Cremers S. Pharmacokinetics and ovarian suppression during use of a contraceptive vaginal ring in normal weight and obese women. J Obstet Gynecol 2012; 207(1):39.e1-6.
Yadav VK, Oury F, Tanaka KF, Thomas T
, Wang Y, Cremers S, Hen R, Krust A, Chambon P, Karsenty G. Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications. J Exp Med. 2011 Jan 17;208(1):41-52.Thomas T
, Ginsberg H. Development of apolipoprotein B antisense molecules as a therapy for hyperlipidemia. Current Atheroscler Rep 2010; 12(1):58-65.Thomas T
, Ginsberg H. Targeting ApoB as a therapeutic approach for the treatmentof dyslipidemia: the potential role of mipomersen. Clin Lipidol, 2010; 5(4):457-464.