Our research in the Laboratory of Transfusion Biology uses in vitro systems, mouse models, and human studies to investigate important problems related to red blood cell biology and animal welfare. We are interested in how iron released from red blood cells following transfusion affects infectious risk and biofilm formation. In addition, we study the role of iron deficiency, iron supplementation, and iron metabolism in the biology of malaria, bacterial infections, and co-infections of malaria and bacterial pathogens. Our studies incorporate the use of novel analgesics and refinements in study endpoints to improve animal welfare and study design.
Associate Director, Institute of Comparative Medicine
, Bandyopadhyay S, Slate A, Francis RO, Francis KP, Spitalnik SL,
Fidock DA, Brittenham GM, Hod EA. Transfusion of stored blood impairs host
defenses against Gram-negative pathogens in mice. Transfusion. 2014 Nov;54(11):2842-51.
Slate AR, Bandyopadhyay S, Francis KP, Papich MG, Karolewski B, Hod EA,Prestia KA
. Efficacy of enrofloxacin in a mouse model of sepsis. J Am Assoc Lab Anim Sci. 2014 Jul;53(4):381-6.
Baker SW, Prestia KA
, Karolewski B. Using reduced personal protective
equipment in an endemically infected mouse colony. J Am Assoc Lab Anim Sci. 2014
Hubbard AC, Bandyopadhyay S, Wojczyk BS, Spitalnik SL, Hod EA, Prestia KA
. Effect of dietary iron on fetal growth in pregnant mice. Comp Med. 2013 Apr;63(2):127-35. Prestia KA
, Sosunov EA, Anyukhovsky EP, Dolmatova E, Kelly CW, Brink PR, Robinson RB, Rosen MR, Duffy HS. Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease Incidence of Ventricular Tachycardia in Mice. Front Physiol. 2011 Jan 31;2:1.
Anyukhovsky EP, Sosunov EA, Kryukova YN, Prestia K
, Ozgen N, Rivaud M, Cohen IS, Robinson RB, Rosen MR. Expression of skeletal muscle sodium channel (Nav1.4) or connexin32 prevents reperfusion arrhythmias in murine heart. Cardiovasc Res. 2011 Jan 1;89(1):41-50.
Yamada KP, Prestia K
, Dholakia U, Shoulson R. Revisiting approval protocols:
re-review not required. Lab Anim (NY). 2010 Jun;39(6):166.
Coronel R, Lau DH, Sosunov EA, Janse MJ, Danilo P Jr, Anyukhovsky EP, Wilms-Schopman FJ, Opthof T, Shlapakova IN, Ozgen N, Prestia K
, Kryukova Y, Cohen IS, Robinson RB, Rosen MR. Cardiac expression of skeletal muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial
infarction. Heart Rhythm. 2010 Aug;7(8):1104-10
Dholakia U, Bandyopadhyay S, Hod EA, Prestia KA
. Determination of Red Blood Cell Survival in C57BL/6 and C57BL/6-Tg(UBC-GFP) Mice. Comp Med. 2015 (Accepted for Publication)
Honors and Awards
The Society of Phi Zeta Veterinary Honor Society
Joseph E. Salsbury Veterinary Medical Scholarship