Research Faculty

630 West 168th Street
Room P&S 14-434
New York, NY 10032

Phone: 212-305-2204
Fax: 212-305-3693
Education and Training
M.D. 1978 University of Chicago
Research Fellowship 1980-81 University
of Rochester
Research Fellowship 1983-85 National Institutes of Health
Residency 1978-80 University of
Rochester School of Medicine
Residency 1981-83 University of
Rochester School of Medicine
Steven Spitalnik, M.D.
Professor of Pathology and Cell Biology
Vice Chairman, Laboratory Medicine
Research Summary

My research program in the Laboratory of Transfusion Biology uses in vitro systems, mouse models, and human studies to investigate important problems related to red blood cell biology. We are particularly interested in improving the quality of red blood cell transfusions, and preventing or ameliorating the adverse effects resulting from this therapeutic intervention. As a result, we study the consequences of refrigerated storage, alloimmunization, and hemolytic transfusion reactions. We have a particular interest in the role of oxidative stress during refrigerated storage of red blood cells and its effects on red blood cell storage quality. In addition, we study the role of iron deficiency, iron supplementation, and iron metabolism in the biology of malaria, bacterial infections, and co-infections of malaria with bacterial pathogens. Results from these studies provided the impetus for the “iron hypothesis” to explain some of the adverse effects of red blood cell transfusion, particularly with regard to infectious disease.


CP Board Review

Service Activities

Director of Laboratory Medicine with subspecialty interest and expertise in transfusion medicine

As Director of Clinical Laboratories at the CUMC campus of the NYPH, I coordinate the clinical service, educational, and scholarly activities of our division.
Selected Publications

Zimring JC, Smith N, Stowell SR, Johnsen JM, Bell LN, Francis RO, Hod EA, Hendrickson JE, Roback JD, Spitalnik SL. Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. Transfusion 54:137-148, 2014.

LaRocca TJ, Stivison EA, Hod EA, Spitalnik SL, Cowan PJ, Randis TM, Ratner AJ. Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. mBio 5(5):e01251-14, 2014.

Prestia K, Bandyopadhyay S, Slate A, Francis RO, Francis KP, Spitalnik SL, Fidock DA, Brittenham GM, Hod EA. Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice. Transfusion 54:2842-2851, 2014.

Wojczyk BS, Kim N, Bandyopadhyay S, Francis RO, Zimring JC, Hod EA, Spitalnik SL. Macrophages clear refrigerator storage-damaged RBCs and subsequently secrete cytokines in vivo, but not in vitro, in a murine model. Transfusion 54:3186-3197, 2014.

5. LaRocca T, Stivison E, Mal-Sarkar T, Hooven T, Hod E, Spitalnik SL, Ratner A. CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Cell Death and Disease 6:e1773; doi:10.1038/cddis.2015.135, 2015.

Xu JZ, Francis RO, Lerebours Nadal LE, Shirazi M, Jobanputra V, Hod EA, Jhang JS, Stotler BA, Spitalnik SL, Nicholas SW. G6PD Deficiency in an HIV Clinic Setting in the Dominican Republic. American Journal of Tropical Medicine and Hygiene 93:722-729, 2015.

Waterman HR, Kapp LM, Howie HL, Hod EA, Spitalnik SL, Zimring JC. Analysis of 24-h recovery of transfused stored RBCs in recipient mice of distinct genetic backgrounds. Vox Sanguinis 109:148-154, 2015.

L’Acqua C, Bandyopadhyay S, Francis RO, McMahon DJ, Nellis M, Sheth S, Kernie SG, Brittenham GM, Spitalnik SL, Hod EA. Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children. American Journal of Hematology 90:915-920, 2015.

Zimring JC, Spitalnik SL. Pathobiology of haemolytic transfusion reactions. Annual Review of Pathology 10:83-110, 2015.

Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NLC, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S for the State of the Science in Transfusion Medicine Working Groups. 2015 Proceedings of the National Heart, Lung, and Blood Institute’s State of the Science in Transfusion Medicine Symposium. Transfusion 55:2282-2290, 2015.

Calabro S, Gallman A, Gowthaman U, Liu D, Chen P, Liu J, Krishnaswamy JK, Nascimento MSL, Xu L, Patel SR, Williams A, Tormey CA, Hod EA, Spitalnik SL, Zimring JC, Hendrickson JE, Stowell SR, Eisenbarth SC. Bridging channel dendritic cells induce immunity to transfused red blood cells, Journal of Experimental Medicine 213:887-896, 2016.
Honors and Awards

1974 - Phi Beta Kappa, Princeton University

1989-1992 - Mallinckrodt Scholar

1995 - Peter C. Nowell Teaching Award, University of Pennsylvania

1996 - Leonard Berwick Memorial Teaching Award, University of Pennsylvania

1998 - Christian R. and Mary F. Lindback Foundation Teaching Award, University of Pennsylvania

2002 - Faculty Mentor Award, 4th Annual Marvin J. Hoffman Day, University of Rochester

2003 - Eric A. Schenk Award for Excellence in Teaching, University of Rochester

2005- Gerald T. Evans Award for outstanding leadership and service to the Academy, Academy of Clinical Laboratory Physicians and Scientists

2013- Graham A. Jamieson Memorial Lectureship, American Red Cross

2013- Emily Cooley Award and Lectureship, American Association of Blood Banks
Committees , Council, and Professional Society Memberships

Academy of Clinical Laboratory Physicians and Scientists

Representative to the Council of Academic Societies

American Association of Blood Banks

American Society for Clinical Investigation

American Society of Investigational Pathology

International Glycoconjugate Society

Society for Glycobiology

Society for Leukocyte Biology

American Society of Hematology

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