Using both human and animal studies we are investigating the pathophysiological consequences of oxidative stress that occurs during the refrigerated storage of red blood cells before transfusion.
Director, Special Hematology and Coagulation Laboratory, Columbia University Medical Center-NYPH
, Jhang JS, Pham HP, Hod EA, Zimring JC, Spitalnik SL. Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks. Vox Sanguinis
. (2013); 105: 271-282.Francis RO
, Jhang J, Hendrickson JE, Zimring JC, Hod EA, Spitalnik SL. Frequency of
glucose-6-phosphate dehydrogenase-deficient red blood cell units in a metropolitan transfusion service. Transfusion
. (2013); 53:606-611.
Raciti PM, Francis RO
, Spitalnik PF, Schwartz J, Jhang JS. Acquired hemoglobin variants and exposure to glucose-6-phosphate dehydrogenase deficient red blood cell units during exchange transfusion for sickle cell disease in a patient requiring antigen-
matched blood. Journal of Clinical Apheresis
. (2013); 28:325-329.
Zimring JC, Smith N, Stowell SR, Johnsen JM, Bell LN, Francis RO
, Hod EA, Hendrickson JE, Roback JD, Spitalnik SL. Strain-specific RBC storage, metabolism, and eicosanoid generation in a mouse model. Transfusion
published online May 30, (2013); DOI 10.1111/trf.12264.
Honors and Awards
The Harold Amos Medical Faculty Development Program (awardee), Robert Wood Johnson Foundation - 2013
The Dr. Joseph G. Fink Laboratory Medicine Faculty Teaching Award, Columbia University Medical Center, College of Physicians and Surgeons, Department of Pathology and Cell Biology - 2013
Committees , Council, and Professional Society Memberships
Academy of Clinical Laboratory Physicians and Scientists (ACLPS)
College of American Pathologists
American Society for Clinical Pathology
American Association of Blood Banks
Blood Banks Association of New York State
American Society of Hematology