Research Faculty

Address
630 West 168th Street
VC 14-238
New York, NY 10032

Phone: 212-305-8488
Fax:

sml2179@columbia.edu
Education and Training
Affiliations
Gastointestinal
Transplant
Liver


Stephen M. Lagana, MD
Assistant Professor of Clinical Pathology
Research Summary

I am interested in translational research projects in gastrointestinal/liver pathology, particularly questions related to best practices in diagnostics as well as emerging theranostic markers in neoplasms.
Service Activities

Gastrointestinal pathology, hepatic pathology, and general surgical pathology
Selected Publications

Peer reviewed publications:

Chen, X., Lagana, S. M., Poneros, J., Kato, T., Remotti, F., He, H., Kaminsky, D. and Hamele Bena, D. (2013), Cytological diagnosis of angiosarcoma arising in an immunosuppressed patient 6 years after multi-visceral transplantation. Diagn. Cytopathol.. doi: 10.1002/dc.23068

Lagana SM, Moreira, RK, Remotti HE, Bao F. Glutamine synthetase, Heat-shock Protein 70 and Glypican-3 in Intra-hepatic Cholangiocarcinoma and Tumors Metastatic to Liver. Accepted, Applied Immunohistochemistry and Molecular Morphology.

Lagana SM, Salomao M, Bao F, Moreira RK, Lefkowitch, J, Remotti HE. Utility of an Immunohistochemical Panel Consisting of Glypican-3, Heat Shock Protein-70, and Glutamine Synthetase in the Distinction of Low-grade Hepatocellular Carcinoma from Hepatocellular Adenoma. Applied Immunohistochemistry and Molecular Morphology. 2013 Mar;21(2):170-6. doi: 10.1097/PAI.0b013e31825d527f.

Lagana SM, Taub RN, Borczuk AC. Utility of Glucose Transporter 1 in the Distinction of Benign and Malignant Thoracic and Abdominal Mesothelial Lesions. Accepted, in press, Archives of Pathology and Laboratory Medicine.

Guo-Xia Tong, Lorenzo Memeo, Cristina Colarossi, Diane Hamele-Bena, Cristina Magi-Galluzzi, Ming Zhou, Stephen M. Lagana, Lara Harik, Jennifer M. Oliver-Krasinski, Mahesh Mansukhani, Lorenzo Falcone, Hanina Hibshoosh, and Kathleen O’Toole. PAX8 and PAX2 Immunostaining Facilitates the Diagnosis of Primary Epithelial Neoplasms of the Male Genital Tract. Am J Surg Pathol. 2011 Oct;35(10):1473-83.

Lagana SM, Hanna RF, Borczuk AC. Pleomorphic (Spindle and Squamous Cell) Carcinoma Arising in a Peripheral Mixed Squamous and Glandular Papilloma in a 70 Year Old Man. Arch Pathol Lab Med. 2011 Oct;135(10):1353-6.

Lagana SM, Moreira RK, Lefkowitch JH.Hepatic Granulomas: Pathogenesis and Differential Diagnosis. Clin Liver Dis. 2010 Nov;14(4):605-17.PMID: 21055685

Lagana SM, Parwani AV, Nichols L. Cardiac Sarcoidosis. A Pathology Focused Review. Arch Pathol Lab Med. 2010 Jul;134(7):1039-46.

Nichols L, Lagana S, Parwani A. Coronary Artery Aneurysm: a Review and Hypothesis Regarding Etiology. Arch Pathol Lab Med. 2008 May;132(5):823-8. Review.

London B, Michalec M, Mehdi H, Zhu X, Kerchner L, Sanyal S, Viswanathan PC, Pfahnl AE, Shang LL, Madhusudanan M, Baty CJ, Lagana S, Aleong R, Gutmann R, Ackerman MJ, McNamara DM, Weiss R, Dudley SC Jr. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias. Circulation. 2007 Nov 13;116(20):2260-8.

Platform presentations:

Mutational analysis by Next Generation Sequencing of Preneoplastic Intestinal Metaplasia in patients with Barrett Esophagus from endoscopic samples. Lagana, Stephen M.; Yao, Yuan; Uehara, Takeshi; Jhala, Nirag, Ganguly, Tapan; Sepulveda, Jorge; Liu, Yang; Brand, Randall; Falk, Gary W., Sepulveda, Antonia R. European Congress of Pathology, 2013, Lisbon, Portugal. 9/1/13.

A comparison of the immunophenotype of hepatocellular carcinoma and non-lesional hepatocytes when analyzed with next-generation markers. Stephen Lagana, Marcela Salamao, Fei Bao, Roger Moreira, Jay Lefkowitch and Helen Remotti. 100th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, TX, USA. 3/1/2011

Abstracts:

HepPar-1 and Arginase-1 in small intestinal and ampullary adenocarcinoma. Stephen Lagana M.D., Susan Hsaio, M.D., Fei Bao, M.D., Antonia Sepulveda M.D. Ph.D., Roger Moreira, M.D., Jay Lefkowitch, M.D., and Helen Remotti, M.D. European Congress of Pathology 2013, Lisbon, Portugal. 9/1/13. Poster 046.

Endoscopic Biopsy Technique and Biopsy Orientation in the Evaluation of Celiac Disease. Melissa Latorre MD, Stephen M. Lagana MD, Daniel E. Freedberg MD, Benjamin Lebwohl MD, Govind Bhagat MD, Suzanne K. Lewis MD, Peter H.R. Green MD. Digestive Disease Week 2013, Orlando, FL, USA. 8/19/13.

Bile Salt Export Pump (BSEP): A Sensitive and Specific Marker of Hepatocytic Differentiation in Liver Tumors. Lagana SM, Remotti H, Moreira RK. 101st Annual meeting of the United States and Canadian Academy of Pathology, Vancouver, BC, Canada. Poster #248. Tuesday, March 20, 2012.

CD146 Expression in Pleural and Peritoneal Mesothelioma. Lagana SM, Taub RN, Borczuk AC. 101st Annual meeting of the United States and Canadian Academy of Pathology, Vancouver, BC, Canada. Poster #296. Wednesday, March 21, 2012.

Immunophenotypic Subtypes of Hepatic Adenomas in a Large Tertiary Care Center in the United States. McMillen E, Lagana SM, Bao F. 101st Annual meeting of the United States and Canadian Academy of Pathology, Vancouver, BC, Canada. Poster #255. Tuestday, March 20, 2012.

Glutamine synthetase, Heat-shock Protein 70, and Glypican-3 in Intra- hepatic Cholangiocarcinoma. SM Lagana, Roger K. Moreira, Helen Remotti, Fei Bao. American Socitey of Clinical Pathology. Las Vegas, NV.October 21, 2011

Despite Warning, Gadolinium Is Safe in Patients with Liver Disease.
R F Hanna, MD, New York, NY; M R Escudero, MD; V Miloushev, MD; S Lagana; MD; E Kulon, MD; M R Prince, MD, PhD. Radiological Society of North America, 97th Annual meeting. Chicago, IL. November 27, 2011

MRI has greater sensitivity than 64-slice CT for detecting hepatocellular carcinoma in cirrhotic patients. Robert F Hanna, Stephen Lagana, Roger K Moreira, Inna Postolov, Jean Emond, Martin R Prince. 19th Annual Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine in Montreal, Canada, May 2011.

Diagnostic and Histogenetic Significance of PAX2 and PAX8 Expression in Three Uncommon Tumors of the Male Lower Urogenital Tract . Stephen M. Lagana, MD, Guo-Xia Tong, MD, PhD, Lorenzo Memeo, MD, Cristina Colarossi, MD, Mahesh Mansukhani, MD, Hanina Hibshoosh, MD, and Kathleen O’Toole, MD. American Society of Clinical Pathology Annual Metting, October 2010, San Francisco, CA.

Glucose Transporter-1 Immunostaining Differentiates Intestinal Metaplasia With Dysplasia From Adenocarcinoma in Barrett Esophagus. Lagana, SM, Remotti F, Remotti H. College of American Pathologists Annual Meeting. September 2010, Chicago, IL.
Utility of Glucose Transporter 1 in the differentiation of peritoneal and pleural mesothelioma from non-malignant mesothelium.

SM Lagana, RN Taub and AC Borczuk. United States and Canadian Academy of Pathology 99th Annual Meeting. March 23 2010, Washington, D.C.

A Mutation in the Glycerol-3-Phosphate Dehydrogenase 1-Like Gene (GPD1L) Causes Brugada Syndrome. Barry London, MD, PhD, Shamarendra Sanyal, MD, PhD, Michael Michalec, BS, Arnold E. Pfahnl, MD, PhD, Lijuan L. Shang, PhD, Laurie Kerchner, BS, Stephen Lagana, BA, Ryan G. Aleong, MD, Haider Mehdi, PhD, Rebecca Gutmann, RN, BSN, Raul Weiss, MD and Samuel C. Dudley, Jr., MD, PhD. Heart Rhythm Society, Boston MA, May 3, 2006.


Committees , Council, and Professional Society Memberships

College of American Pathologists, United States and Canadian Academy of Pathology.

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