Research Faculty

Address
622 W 168th Street
HP 4-419
New York, NY 10032

Phone: 646-317-4618
Fax:

yct2103@columbia.edu
Yvette C. Tanhehco, PhD, MD, MS
Assistant Professor of Pathology and Cell Biology
Director of Hemotherapy and Cellular Therapy
Assistant Director of Transfusion Medicine
Research Summary

I am interested in studying thrombotic disorders such as thrombotic thrombocytopenic purpura and heparin induced thrombocytopenia, especially the role of plasma exchange for the treatment of these disorders. I am also interested in studying novel peripheral blood stem cell mobilization agents and understanding the factors that contribute to a successful mobilization.
Service Activities

Assistant Director of Transfusion Medicine, New York Presbyterian Hospital, Columbia University Medical Center

Director of Cellular Therapy and Hemotherapy, New York Presbyterian Hospital, Columbia University Medical Center

Attending physician in Transfusion Medicine
Selected Publications

A. Peer Reviewed Articles

1. Shumaker DK, Lee KK, Tanhehco YC, Craigie R, Wilson KL: LAP2 binds to BAF-DNA Complexes: Requirement for the LEM Domain and Modulation by Variable Regions. EMBO J 2001; 20:1754-1764.

2. Moore SM, Cannon JS, Tanhehco YC, Hamzeh FM, Ambinder RF: Induction of Epstein-Barr Virus Kinases to Sensitize Tumor Cells to Nucleoside Analogues. Antimicrob Agents Chemother 2001; 45:2082-2091.

3. Rosengart TK, Finnin EB, Kim DY, Samy SA, Tanhehco Y, Ko W, Lang SJ, Krieger KH, Isom OW: Open Heart Surgery in the Elderly: Results from a Consecutive Series of 100 Patients Aged 85 Years or Older. Am J Med 2002; 112:143-147.

4. Matsui WH, Huff CA, Wang Q, Malehorn MT, Barber J, Tanhehco Y, Smith BD, Civin CI, Jones RJ: Characterization of Clonogenic Multiple Myeloma Cells. Blood 2004; 103:2332-2336.

5. Fu DX, Tanhehco YC, Chen J, Foss CA, Fox J, Lemas V, Chong JM, Ambinder RF, Pomper MG: Virus-Associated Tumor Imaging by Induction of Viral Gene Expression. Clin Cancer Res 2007; 13:1453-1458.

6. Fu DX, Tanhehco Y, Chen J, Foss CA, Fox J, Chong JM, Fukayama M, Sgouros G, Kowalski J, Pomper MG, Ambinder RF: Bortezomib-Induced Enzyme-Targeted Radiotherapy in Herpesvirus-Associated Tumors. Nat Med 2008; 14:1118-22.

7. Tanhehco YC, Palmer OMP, Derrico LS, Sepulveda JL, Blair HC: Biases in Antibody-Based Single-Phase Assays for Free Thyroxine due to Protein-bound Analyte. Clin Chim Acta 2009; 406 (1-2):176-178.

8. Sepulveda JL, Tanhehco YC, Frey M, Guo L, Cropcho LJ, Blair HC: Variation in Human Erythrocyte Membrane Fatty Acid Composition: Correlation with Vascular Disease. Arch Pathol Lab Med 2010; 134 (1):73-80.

9. Tanhehco YC, Adamski J, Sell M, Cunningham K, Eisenmann C, Magee D, Stadtmauer E, O’Doherty U. Plerixafor Mobilization Leads to a Lower Ratio of CD34+ Cells to Total Nucleated Cells Which Results in Greater Storage Costs. J Clin Apher 2010; 25 (4):202-208.

10. Tanhehco YC, Rux AH, Sachais BS. Low Density Lipoprotein Apheresis Reduces PF4 on the Surface of Platelets: a Possible Protective Mechanism Against HITT. Transfusion 2011; 51 (5):1022-1029.

B. Reviews

Tanhehco YC and Berns JS: Red Blood Cell Transfusion Risks in Patients with End-Stage Renal Disease. Semin Dial 2012 Sep;25(5):539-44.

C. Editor’s Choice

1. Tanhehco YC. Giving Statins a Run for Their Money? Sci Transl Med 2012; 4 (124):124ec43.

2. Tanhehco YC. Mirror, Mirror, on the Wall, Which Way Will the Balance Fall? Sci Transl Med 2012; 4(129):129ec63.

3. Tanhehco YC. Stressing Out the Endoplasmic Reticulum. Sci Transl Med 2012; 4(133):133ec82.

4. Tanhehco YC. Casting a Wide NET for TRALI. Sci Transl Med 2012; 4(137):137ec100.

5. Tanhehco YC. Getting the Yin Without the Yang with Antiplatelet Therapy. Sci Transl Med 2012; 4(141):141ec118.

6. Tanhehco YC. CD39 to the Rescue. Sci Transl Med 2012; 4(145):145ec137.

7. Tanhehco YC. A Silver Bullet for T Cell Malignancies? Sci Transl Med 2012; 4(149):149ec155.

8. Tanhehco YC. Neutralizing Neutrophil Invasion. Sci Transl Med 2012; 4(153):153ec174.

9. Tanhehco YC. SINES of a New Leukemia Treatment. Sci Transl Med 2012; 4(157):157ec193.
Current Projects

Development of an apheresis registry
Development of a multi-institutional thrombotic microangiopathy (eg thrombotic thrombocytopenic purpura and hemolytic uremic syndrome) registry

Honors and Awards

1998 Golden Key National Honor Society
2000 Honorable Mention, Graduate Research Fellowship, National Science Foundation
2005 Summer Research Fellowship, East Asia and Pacific Summer Institutes, National Science Foundation

Committees , Council, and Professional Society Memberships

American Association of Blood Banks
American Society for Apheresis
American Society of Hematology


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