Research Faculty

Address
630 West 168th Street
PH West 1590B
New York, NY 10032

Phone: 212-305-6360
Fax:

jls2282@cumc.columbia.edu
Education and Training
MD, 1984, University of Lisbon
PhD, 1994, Cell and Molecular
Biology, Baylor College of Medicine
Residency in Clinical Pathology, 1987-1993, Baylor College of
Medicine
Fellowship in Transfusion Medicine, 1993-1994, Baylor College of
Medicine
Jorge L. Sepulveda, M.D., Ph.D.
Associate Professor of Pathology and Cell Biology
Research Summary

My current research centers on Systems Biology approaches to understanding molecular mechanisms regulating cellular phenotypes, in particular focusing on the transformation from a physiologic to a pathologic state. A particular angle of interest is the integration of large scale genomic, transcriptomic, epigenetic, proteomic, and metabolomic data to derive a molecular “holistic” approach to understanding the development of gastro-intestinal cancers (particularly of the esophagus and stomach) and in a separate project, the transition from a healthy heart to cardiac hypertrophy and heart failure. We aim at a comprehensive, integrated view of pathology to develop personalized diagnostic, prognostic, and therapeutic approaches to disease.
Service Activities

Associate Director for Laboratory Medicine and Medical Director of Laboratory Informatics

My clinical interests are centered on efficient laboratory management and provision of user-friendly laboratory information and interpretation to optimize patient care. As a clinical laboratorian and research scientist, I am interested in using large-scale data analysis and computational approaches to understand and guide efficient use of clinical laboratory tests to improve patient care.
Selected Publications

1. Del Portillo A, Lagana SL, Yuan Y, Uehara T, Jhala N, Tapan G, Nagy P, Gutierrez J, Luna A, Abrams J, Yang L, Brand R, Sepulveda JL, Falk, GW, Sepulveda, AR. Evaluation of Mutational Testing of Pre-neoplastic Barrett’s Mucosa by Next Generation Sequencing of FFPE Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett’s Esophagus. J Mol Diagn., 17(4), 412-419, 2015. Press release June 8, 2015.

2. Sepulveda JL, Gutierrez-Pajares JL, Luna A, Yao Y, Tobias JW, Thomas S, Woo Y, Georgio F, Komissarova E, Califano A, Wang TC, Sepulveda AR. High Definition CpG Methylation of Novel Genes in Gastric Carcinogenesis Identified by Next Generation Sequencing. Submitted (2015).

3. Pivovarov, R, Albers, DJ, Sepulveda, JS, Elhadad, N. “Identifying and mitigating biases in EHR laboratory tests”. J Biomed Inform. 51:24-34, 2014.

4. Pivovarov, R, Albers, DJ, Hripcsak, G, Sepulveda, JS, Elhadad, N. “Identifying and Mitigating Biases in EHR Laboratory Tests”. J. Biomed. Informatics, 51:24-34, 2014 (Epub PMID: 24727481).

5. Pivovarov, R, Albers, DJ, Hripcsak, G, Sepulveda, JS, Elhadad, N. “Temporal Trends of Hemoglobin A1C Testing”. J Am Med Inform Assoc, 21(6):1038-44., 2014 (Epub PMID: 24928176)

6. Sepulveda JL, Young, DS. "The Ideal Laboratory Information System." Archives of Pathology and Laboratory Medicine, 137(8), 1129-40, 2013.

7. Sepulveda JL, "Challenges in routine clinical chemistry: proteins and enzymes." In Dasgupta, A. and Sepulveda, JL editors. "Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction", Elsevier, available June 2013.

8. Sepulveda, JL, "Challenges in routine clinical chemistry: analysis of small molecules." In Dasgupta, A. and Sepulveda, JL editors. "Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction", Elsevier, available June 2013.

9. Sepulveda, JL, "Variation, Errors, and Quality in the Clinical Laboratory." In Dasgupta, A. and Sepulveda, JL editors. "Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction", Elsevier, available June 2013.

10. Sepulveda, JL "Protein markers for digestive tract tumors." In Sepulveda, AR and Lynch, JP (ed): "Molecular Pathology of Gastrointestinal Neoplasia", Springer LLC, 2013

11. Sepulveda, JL. "Pharmacogenomics of psychoactive drugs", in "Pharmacogenomics in Clinical Therapeutics." In Dasgupta, A and Langman, LJ (ed): "Pharmacogenomics in Clinical Therapeutics", Willey-Blackwell, 2012.

12. Sepulveda, JL. "Microarray technology and other methods in pharmacogenomics testing." In Dasgupta, A and Langman, LJ (ed): "Pharmacogenomics in Clinical Therapeutics", Willey-Blackwell, 2012.

13. Sepulveda, JL. "Methodologies in Pharmacogenomics Testing." In Dasgupta, A and Langman, LJ (ed),"Pharmacogenomics of Alcohol and Drugs of Abuse", CRC Press, Boca Raton, FL, 2012, 211-228.

14. Sepulveda, JL. "Genetic Aspect of Opiate Metabolism and Addiction." In Dasgupta, A and Langman, LJ (ed),"Pharmacogenomics of Alcohol and Drugs of Abuse", CRC Press, Boca Raton, FL, 2012, 165-194.

15. Sepulveda, JL, Tanhehco, YC, Frey, M, Guo, L,Cropcho, LJ, Gibson, KM, Blair, HC. “Variation in Human Erythrocyte Membrane Unsaturated Fatty Acids: Correlation with Cardiovascular Disease.” Archives of Pathology and Laboratory Medicine, 2010, 134, 73-80.

16. Chen H, Huang XN, Yan W, Chen K, Guo L, Tummalapali L, Dedhar S, St-Arnaud R, Wu C, Sepulveda, JL. “Role of the Integrin-linked kinase / PINCH / alpha-parvin complex in cardiac myocytes.” Laboratory Investigation, 2005, 85, 1342-1352.

17. Chen, H, Huang, XN, Stewart, AF, Sepulveda, JL. “Gene expression changes associated with fibronectin-induced cardiac myocyte hypertrophy.” Physiological Genomics, 2004, 18, 273-283.

18. Sepulveda JL, Vlahopoulos S, Iyer D, Belaguli N, Schwartz RJ. “Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity.” Journal of Biological Chemistry, 2002, 277(28):25775-25782

19. Sepulveda JL, Belaguli N, Nigam V, Chen CY, Nemer M, Schwartz RJ. “GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression.” Molecular and Cellular Biology, 1998, 18: 3405-3415

Committees , Council, and Professional Society Memberships

Academy of Clinical Laboratory Physicians and Scientists (Executive Committee)

Association for Molecular Pathology (Informatics Subdivision Nominating Committee Representative)

American Association for Clinical Chemistry

College of American Pathologists (Fellow)

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