Research Faculty

Address
630 West 168th Street
P&S 14-434
New York NY 10032

Phone: 212-342-5648
Fax:

eh2217@columbia.edu
Education and Training
BS 1998 Technion – Israel Institute of Technology

MD 2005 Mt. Sinai School of Medicine

Residency 2008 Columbia University Medical Center

Fellowship 2010 Joint program – Columbia University Medical Center & New York Blood Center

Board certified in CP and Transfusion Medicine

Eldad Arie Hod, M.D.
Associate Professor of Pathology and Cell Biology
Research Summary

Our translational research using cell culture models, mouse models, and human subjects focuses on the effect of modulating iron status on innate immune mechanisms. For example, we are interested in how iron released from red blood cells cleared from the circulation following transfusion affects infectious risk in patients. In addition, we are interested in other outcomes of red cell transfusion such as alloimmunization and thrombosis. Finally, we are interested in how iron availability affects biofilm formation by microbial pathogens.

Service Activities

Attending Physician Division of Transfusion Medicine and Cell Therapy

Director, Center for Advanced Laboratory Medicine (CALM)

Assistant Director, Core Laboratories, New York-Presbyterian Hospital

Selected Publications

Hendrickson JE, Hod EA, Spitalnik SL, Hillyer CD, Zimring JC. Stored murine HOD RBCs induce a stronger alloimmune response than freshly collected and transfused RBCs. Transfusion. (2010);50:642-8.

Hod EA, Zhang N, Sokol SA, Wojczyk BS, Francis RO, Ansaldi D, Francis KP, Della-Latta P, Whittier S, Sheth S, Hendrickson JE, Zimring JC, Brittenham GM, Spitalnik SL. Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. Blood. (2010);115: 4284-92.

Jang J, Hod EA, Spitalnik SL, Frenette P. CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions. J Clin Invest. (2011);121:1397-401.

Hendrickson JE, Hod EA, Cadwell CM, Eisenbarth SC, Spiegel DA, Tormey CA, Spitalnik SL, Zimring JC. Rapid clearance of transfused murine RBCs is associated with recipient cytokine storm and enhanced alloimmunogenicity. Transfusion. (2011); 51:2445-54.

Hod EA, Brittenham GM, Billote GB, Francis RO, Ginzburg YZ, Hendrickson JE, Jhang J, Schwartz J, Sharma S, Sheth S, Sireci A, Stephens HL, Stotler BA, Wojczyk BS, Zimring JC, Spitalnik SL. Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron. Blood. (2011);118:6675-82.

Smith NH, Hod EA, Spitalnik SL, Zimring JC, Hendrickson JE. Transfusion in the absence of inflammation induces antigen specific tolerance to murine RBCs. Blood. 2011 in press.

Hod EA, Spitalnik SL. Stored red blood cell transfusions: Iron, inflammation, immunity, and infection. Transfus Clin Biol. (2012);19(3):84-9.

Callan MB, Patel RT, Rux AH, Bandyopadhyay S, Sireci AN, O’Donnell PA, Ruane T, Sikora T, Marryott K, Sachais BS, Hod EA. Transfusion of 28 Day-Old Leukoreduced or Non-Leukoreduced Stored Red Blood Cells Induces an Inflammatory Response in Healthy Dogs. Vox Sang. (2013) Nov;105(4):319-327.

Honors and Awards

1994
Westinghouse Finalist

2004
Arnold P. Gold Humanism in Medicine Honors Society

2005
Inducted Alpha Omega Alpha (AOA)

2005
Medical Student Basic Science Research Award, Mt. Sinai School of Medicine

2007-2009
Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists

2008
College of American Pathologists Research Scholar

2009-2010
AABB-Fenwal Transfusion Medicine Fellow Scholarship Award

2010
Louis V. Gerstner, Jr., Scholar

2010-2012
National Institutes of Health (NIH) Clinical Loan Repayment Program (LRP) Award

2010
National Blood Foundation (NBF) Young Investigator Scholarship

2010-2014
National Institutes of Health (NIH) Clinical Loan Repayment Program (LRP) Award

2010
National Blood Foundation (NBF) Young Investigator Scholarship

Committees , Council, and Professional Society Memberships

Academy of Clinical Laboratory Physicians and Scientists (ACLPS)
American Association of Blood Banks (AABB)
American Society of Hematology (ASH)
International Society for Blood Transfusion (ISBT)
Keywords

Transfusion, iron, infection, inflammation, innate immunity, macrophage, biofilm


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