Research Faculty

Address
630 West 168th Street
Room 15-402
New York, NY 10032


Phone: 212-305-3300
Fax: 212-305-5498

mls7@columbia.edu
Education and Training
M.D. 1966 University of Chicago
Ph.D. 1967 University of Chicago

Michael Shelanski, M.D., Ph.D.
Department Chairman, Pathology;
Delafield Professor of Pathology & Cell Biology
Research Summary

Our laboratory is investigating the mechanism of memory disruption and synaptic dysfunction in Alzheimer's Disease. We use a combination of cell culture and transgenic animal approaches in an attempt to understand why the overexpression of the amyloid precursor protein (APP) or direct application of its active peptide, A-beta, inhibits intracellular signaling in neuronal cells and leads to alterations of electrical activity, dendritic spine morphology and behavior. These results are extended with analyses of neurons taken from post-mortem Alzheimer's Disease brains. In the past two years our attention has been on the PKA-CREB signaling pathway and on the role of ubiquitin c-terminal hydrolase-L1 (Uch-L1) in regulating these events. We have used both drugs and protein transduction techniques to show that A-beta induced changes, both in culture and in the animal, can be reversed by restoring these pathways to their normal "balance". Other projects involve the induction of neurogenesis in neural stem cells by A-beta raising the possibility of an endogenous repair mechanism in AD, and the analysis of the action of the ginkgolides on neuronal function. The laboratory approaches these questions with a wide range of tools including biochemistry, cell biology, physiology and microscopy.
Selected Publications

Please click the PubMed link below to view Dr. Shelanski's publications:

Honors and Awards

1970-1971, 1973-1974 NINDS Teacher-investigator Award

1973-1974 Guggenheim Foundation Fellow

1995-2001 Jacob Javits Neuroscience Investigator Award

1999-present Member, Institute of Medicine, National Academy of Sciences

2013- Distinguished Service Award from the University of Chicago
Committees , Council, and Professional Society Memberships

1974-1978 Member, Neurology A Study Section

1985-1992, 1999, 2000 Alzheimer's Association

1987-1990 Member, Pharmacological Sciences Study Section, NIGMS

1998, 1999 Special Study Sections for Udall Parkinson's Disease Centers

2000 Special Review Panel, BDCN Study Sections, C SR/NIH

Member, American Association of Neuropathologists
Keywords

Alzheimer's disease, amyloid protein, cyclic AMP, cysteine endopeptidase, enzyme activity, long term potentiation, neural degeneration, neuropathology, protein kinase A, cAMP response element binding protein, cell differentiation, cell growth regulation

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