Research Faculty

Address
630 W 168th Street
P&S 17-401
New York, NY 10032

Phone: 212-305-1476
Fax: 212-342-0420

abn2@columbia.edu
Education and Training
MS London University, England
Ph.D. Surrey University, England
Post-doctoral Fellow Clinical Research Center, P&S, Columbia University, New York

Board Certiifications
Diplomat, American Board of Clinical Chemistry 1994
American Society of Clinical Pathologists 1990
National Registry in Clinical Chemistry: Clinical Chemist 1989

Affiliations
Neurology

Collaborations
Drs. Salvatore DiMauro; Michio Hirano; Hiroshi Mitsumoto; Serge Przedborski
Ali B. Naini, M.Sc., Ph.D.
Associate Professor of Pathology & Cell Biology (in Neurology) at CUMC
Director, Laboratories of Metabolic and Mitochondrial Diseases, Departments of Pathology & Cell Biology and Neurology
Co-Director, Laboratory of Personalized Genomic Medicine
Research Summary

Dr. Ali Naini is Associate Professor of Clinical Pathology and Cell Biology and Director of Laboratory of Molecular Neurogenetics in the Department of Neurology and a member of Houston Merritt Center for Clinical Research. Dr. Naini's research interests include molecular pathogenesis of neurodegenerative diseases and primary CoQ defeiciency. In collaboration with Drs. Hiroshi Mitsumoto, Michio Hirano, and Serge Przedborski, Dr. Naini studies patients affected with amyotrophic lateral sclerosis (Lou Gehrig's Disease) harboring mutations in their Cu/Zn superoxide dismutase gene. In collaboration with Drs. Savatore DiMauro, and Michio Hirano, he also studies patients with mitochondrial encephalomyopathy due to primary CoQ deficiency. Dr. Naini is board certified clinical biochemist and molecular geneticist. He received his graduate training at London University and University of Surrey in the United Kingdom. Dr. Naini joined Neuromuscular group at Houston Merritt Center in 1997 as the director of the Laboratory of Molecular Neurogenetics and Mitochondrial Diseases. Dr. Naini is a regular reviewer of several international journals and is author and co-author of numerous publications related to the pathogenesis and molecular aspects of neurological diseases.


Service Activities

Directing Mitochondrial laboratory and Neurogenetics molecular testing in the Laboratory of Personalized Genomic Medicine
Selected Publications

1. Jobanputra V, Naini A: New Developments in Molecular Diagnosis of Neuromuscular Disorders. Journal of Neurological Disordrs & Stroke 2013, 1:1003.

2. Quinzii C, Hirano M, Naini A*: Cerebellar Ataxia and CoQ10 Deficiency. Journal of Neurological Disordrs & Stroke 2013, 1:1004.(editorial)

3. Lamarca NH, Golden L, John RM, Naini A, De Vivo DC, Sproule DM: Diabetic Ketoacidosis in an Adult Patient With Spinal Muscular Atrophy Type II: Further Evidence of Extraneural Pathology Due to Survival Motor Neuron 1 Mutation? J Child Neurol 2012 (Epub ahead of print).

4. Shanske S, Naini A, Chmait RH, Akman HO, Mansukhani M, Lu J, Hirano M, Dimauro S: Mutation in an mtDNA Protein-Coding Gene: Prenatal Diagnosis Aided by Fetal Muscle Biopsy. J Child Neurol 2013, 28:264-268.

5. Emmanuele V, Lopez LC, Berardo A, Naini A, Tadesse S, Wen B, D'Agostino E, Solomon M, Dimauro S, Quinzii C, Hirano M: Heterogeneity of coenzyme q10 deficiency: patient study and literature review. Arch Neurol 2012, 69:978-983.

6. Qiu C, Kumar S, Guo J, Lu J, Shi S, Kalachikov SM, Russo JJ, Naini AB, Schon EA, Ju J: Mitochondrial single nucleotide polymorphism genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using cleavable biotinylated dideoxynucleotides. Anal Biochem 2012, 427:202-210.

7. Garone C, Rubio JC, Calvo SE, Naini A, Tanji K, Dimauro S, Mootha VK, Hirano M: MPV17 Mutations Causing Adult-Onset Multisystemic Disorder With Multiple Mitochondrial DNA Deletions. Arch Neurol 2012:1-4.

8. Quinzii CM, Tadesse S, Naini A, Hirano M: Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. PLoS One 2012, 7:e30606.

9. Cocchi MN, Giberson B, Berg K, Salciccioli JD, Naini A, Buettner C, Akuthota P, Gautam S, Donnino MW: Coenzyme Q(10) levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation 2012, 83:991-995.

10. Emmanuele V, Lopez LC, Berardo A, Naini A, Tadesse S, Wen B, D'Agostino E, Solomon M, Dimauro S, Quinzii C, Hirano M: Heterogeneity of Coenzyme Q10 Deficiency: Patient Study and Literature Review. Arch Neurol 2012.

11. Greenlee H, Shaw J, Lau YK, Naini A, Maurer M: Lack of Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures. Integr Cancer Ther 2012.

12. Qiu C, Kumar S, Guo J, Lu J, Shi S, Kalachikov SM, Russo JJ, Naini AB, Schon EA, Ju J: Mitochondrial SNP Genotyping by MALDI-TOF Mass Spectrometry Using Cleavable Biotinylated Dideoxynucleotides. Anal Biochem 2012.

Book Chapters

Naini A., Shanske S. Detection of mutation in mtDNA. In L Pon and E Schon (ed). Mitochondria. New York: Academic Press, (2007); 437-463.

DiMauro S, Shanske S, Naini A., Krishna, S. In T.E. Bertorini (ed). Clinical Evaluation and Diagnostic tests for Neuromuscular Disorders. New York: Butterworth Heinemann:, (2002);535-564.

Current Projects

Mitochondrial Encephalopathies: Approaches to treatment
Molecular Pathogenesis of Coenzyme Q10 Deficiency


Committees , Council, and Professional Society Memberships

The American Society of Human Genetics

The Association for Molecular Pathology


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