Dr. Ali Naini is Associate Professor of Clinical Pathology and Cell Biology and Director of Laboratory of Molecular Neurogenetics in the Department of Neurology and a member of Houston Merritt Center for Clinical Research. Dr. Naini's research interests include molecular pathogenesis of neurodegenerative diseases and primary CoQ defeiciency. In collaboration with Drs. Hiroshi Mitsumoto, Michio Hirano, and Serge Przedborski, Dr. Naini studies patients affected with amyotrophic lateral sclerosis (Lou Gehrig's Disease) harboring mutations in their Cu/Zn superoxide dismutase gene. In collaboration with Drs. Savatore DiMauro, and Michio Hirano, he also studies patients with mitochondrial encephalomyopathy due to primary CoQ deficiency. Dr. Naini is board certified clinical biochemist and molecular geneticist. He received his graduate training at London University and University of Surrey in the United Kingdom. Dr. Naini joined Neuromuscular group at Houston Merritt Center in 1997 as the director of the Laboratory of Molecular Neurogenetics and Mitochondrial Diseases. Dr. Naini is a regular reviewer of several international journals and is author and co-author of numerous publications related to the pathogenesis and molecular aspects of neurological diseases.
1. Jobanputra V, Naini A
: New Developments in Molecular Diagnosis of Neuromuscular Disorders. Journal of Neurological Disordrs & Stroke
2. Quinzii C, Hirano M, Naini A
*: Cerebellar Ataxia and CoQ10 Deficiency. Journal of Neurological Disordrs & Stroke
3. Lamarca NH, Golden L, John RM, Naini A
, De Vivo DC, Sproule DM: Diabetic Ketoacidosis in an Adult Patient With Spinal Muscular Atrophy Type II: Further Evidence of Extraneural Pathology Due to Survival Motor Neuron 1 Mutation? J Child Neurol
2012 (Epub ahead of print).
4. Shanske S, Naini A
, Chmait RH, Akman HO, Mansukhani M, Lu J, Hirano M, Dimauro S: Mutation in an mtDNA Protein-Coding Gene: Prenatal Diagnosis Aided by Fetal Muscle Biopsy. J Child Neurol
5. Emmanuele V, Lopez LC, Berardo A, Naini A
, Tadesse S, Wen B, D'Agostino E, Solomon M, Dimauro S, Quinzii C, Hirano M: Heterogeneity of coenzyme q10 deficiency: patient study and literature review. Arch Neurol
6. Qiu C, Kumar S, Guo J, Lu J, Shi S, Kalachikov SM, Russo JJ, Naini AB
, Schon EA, Ju J: Mitochondrial single nucleotide polymorphism genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using cleavable biotinylated dideoxynucleotides. Anal Biochem
7. Garone C, Rubio JC, Calvo SE, Naini A
, Tanji K, Dimauro S, Mootha VK, Hirano M: MPV17 Mutations Causing Adult-Onset Multisystemic Disorder With Multiple Mitochondrial DNA Deletions. Arch Neurol
8. Quinzii CM, Tadesse S, Naini A
, Hirano M: Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. PLoS One
9. Cocchi MN, Giberson B, Berg K, Salciccioli JD, Naini A
, Buettner C, Akuthota P, Gautam S, Donnino MW: Coenzyme Q(10) levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation
10. Emmanuele V, Lopez LC, Berardo A, Naini A
, Tadesse S, Wen B, D'Agostino E, Solomon M, Dimauro S, Quinzii C, Hirano M: Heterogeneity of Coenzyme Q10 Deficiency: Patient Study and Literature Review. Arch Neurol
11. Greenlee H, Shaw J, Lau YK, Naini A
, Maurer M: Lack of Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures. Integr Cancer
12. Qiu C, Kumar S, Guo J, Lu J, Shi S, Kalachikov SM, Russo JJ, Naini AB
, Schon EA, Ju J: Mitochondrial SNP Genotyping by MALDI-TOF Mass Spectrometry Using Cleavable Biotinylated Dideoxynucleotides. Anal Biochem
2012.Book ChaptersNaini A.
, Shanske S. Detection of mutation in mtDNA. In L Pon and E Schon (ed). Mitochondria. New York: Academic Press, (2007); 437-463.
DiMauro S, Shanske S, Naini A.
, Krishna, S. In T.E. Bertorini (ed). Clinical Evaluation and Diagnostic tests for Neuromuscular Disorders. New York: Butterworth Heinemann:, (2002);535-564.