Research Faculty

Address
630 West 168th Street
Room 15-405
New York, NY 10032


Phone: 212-305-3554
Fax: 212-305-4548

jeg5@cumc.columbia.edu
Education and Training
M.D., Ph.D. 1976 NYU School of Medicine
James E. Goldman, M.D., Ph.D.
Professor of Pathology
Research Summary

Glial differentiation in mammalian CNS development; progenitors in the adult CNS, glial pathology

- Our lab is working to understand environmental and lineage control of neuronal and glial fates in the developing CNS. Using viral gene transfer, transgenics, live slice imaging, and culture systems, we are defining the migration of precursor cells from germinal zones of the perinatal rodent forebrain and cerebellum, and the development of these precursors into neurons and glia. We are also interested in how these precursors can be altered to mimic the continued proliferation and migration seen in glial brain tumors.

- Our laboratory also studies the population of cycling precursor cells in the adult CNS to understand their fates under normal and pathological situations. For example, cycling precursors in adult white matter can differentiate into myelinating oligodendrocytes after demyelination. We are currently studying CD82, a member of the tetraspanin family, without which cells of the oligodendrocyte lineage cannot progress from precursor cells to pre-myelinating and myelinating oligodendrocytes.

- Our lab is studying Alexander disease, a degenerative disorder of white matter caused by mutations in the astrocyte intermediate filament protein gene, GFAP. We have found that mutant GFAP accumulation leads to proteasome inhibition, the upregulation of several cell stress pathways and dramatic alterations in astrocyte shape and function. These pathological astrocytes may cause the death of oligodendrocytes and neurons. We have found significant changes in neuronal form and function and are examining the mechanisms by which astrocyte pathology can produce neuronal pathology.

Service Activities

Clinical and Teaching:
Director, Neuropathology Division, Dept. of Pathology, Columbia Presbyterian Medical Center, New York, NY, 1992-present
Surgical neuropathology attending (2.5 months/year)
Brain cuttings (1 per 6 weeks)
Participation in neuropathology microscopic conferences (weekly), neurology CPCs, neuro-oncology conferences, CPCs for 3rd year medical students
Lecturer and group discussion leader, 2nd year neuropathology course for medical students, 1987-2009
Lecturer and group discussion leader, 2nd year Neuroscience course for medical students, 2010-present
Leader, 2nd year neuropathology course for medical students, 1992-1995.
Lecturer, Post-graduate review course in basic and clinical neurosciences, 1990-1997
Lecturer, Pathobiology of Disease, 1991-present
Lecturer, Advanced neurobiology, 1991-present
Lecturer, Principles of Developmental Neurobiology, 2003 – present
Lecturer, Basic Principles of Neuroscience, 2003, 2006-present
Lecturer, Course in Stem Cell Biology, 2008-present
Selected Publications

1. Jang, E-S and Goldman, JE. Pax6 expression is sufficient to induce a neurogenic fate in glial progenitors of the neonatal subventricular zone. PLoS One, 6(6):e20894. Epub 2011 Jun 17.

2. Messing A, Brenner M, Feany MB, Nedergaard M, Goldman, JE: Alexander Disease. J Neurosci 32:5017-5023, 2012.

3. Goldman JE: Astrocyte Development. In NEUROGLIA, 3rd ed., Ransom B and Kettenmann H (eds) Oxford University Press, New York, 2013, pp137-147.

4. Schwartz JH, Barres BA, Goldman JE: The Cells of the Nervous System. In PRINCIPALS OF NEUROSCIENCE 5th ed., Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ (eds). McGraw Hill, New York, 2013, pp.71-99.

5. Tang G, Rios PG, Kuo S-H, Akman O, Rosoklija G, Tanji K, Dwork A, Schon EA, DiMauro S, Goldman JE, Sulzer D. Mitochondrial abnormalities in temporal lobe of autistic brain. Neurobiology of Disease, 54:349-361, 2013.

6. Sosunov AA, Guilfoyle E, Wu X, McKhann GM 2nd, and Goldman JE. Phenotypic Conversions of “Protoplasmic” to “Reactive” Astrocytes in Alexander Disease, J Neurosci, 33:7439-7450, 2013.

7. Mela A and Goldman JE. The tetraspanin CD82 inhibits cMet activation by HGF and promotes oligodendrocyte precursor differentiation, J Neurosci, 33:7952-7960, 2013

Honors and Awards

Phi Beta Kappa, Sigma Xi, Amherst College

1969-1976 Medical Scientist Program Fellow, NYU School of Medicine

1980 Certification: American Board of Pathology, Neuropathology

1981-1985 Recipient, NIH Teacher-Investigator Award

1988-1995 NIH Javits Neuroscience Investigator Award

2000 Moore Award/Best Paper on Clinical-Pathological Correlation, Amer Assoc Neuropathology

2002 Saul Korey lecture, American Assoc. for Neuropathology

2005 Marius Valsammis Memorial Lecture, NY Neuroplex

2006 Rubinstein Award for Best Paper in Neuro-Oncology, Amer Assoc Neuropathology

Committees , Council, and Professional Society Memberships

Current Committees:
Member, Residency Committee, Dept. of Pathology, 1992-present
Member, MD.PhD. Admissions and Advisory Committee, 1999-present
Columbia University Medical Center Stem Cell Initiative, member, Advisory Committee 2010 - present

Society Memberships:
American Association for the Advancement of Science
American Association of Neuropathologists
American Society for Neurochemistry
International Society for Neurochemistry
Society for Neuroscience
Keywords

cellular pathology, gene expression, intermediate filament, leukodystrophy, astrocyte, oligodendrocyte, cell differentiation, complementary DNA, free radical oxygen, gene mutation, genetic transcription, genetic translation, heat shock proteins, neuropathology, Alexander disease, myelination

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