Research Faculty

Address
3959 Broadway
CHC - Room 406b
New York, NY 10032


Phone: 212-305-8049
Fax: 212-305-7436

bl2185@cumc.columbia.edu
Education and Training
1987 B.Sc.
University of the Witwatersrand, S.A.
1988 B.Sc. (Honors)
University of the Witwatersrand, S.A.
1991 M.Sc. (Med)
University of the Witwatersrand, S.A.
1999 Ph.D
Mount Sinai School of Medicine



Affiliations
Genetics & Development
Brynn Levy, M.Sc.(Med)., Ph.D.
Director, Clinical Cytogenetics Laboratory;
Co-Director, Personalized Genomic Medicine
Professor of Pathology & Cell Biology at CUMC
Research Summary

My principal research interest is in "Reproductive Genetics". The spectrum of interests covered under the topic of "Reproductive Genetics" is quite broad encompassing the study of mechanisms involved in normal sex differentiation, preimplantation genetic diagnosis (PGD), critical gene expression at implantation, factors that contribute to infertility, the etiology of miscarriages, elements that are critical for healthy pregnancies, the improvement of current prenatal diagnostic tests and the development of non-invasive prenatal screening tests.

My laboratory has optimized a full range of molecular cytogenetic techniques such as fluorescence in situ hybridization (FISH), Multi-color FISH, comparative genomic hybridization (CGH) and SNP oligonucleotide microarray analysis (SOMA), for the analysis of clinical and neoplastic specimens which are not suitable for chromosome analysis by standard cytogenetic techniques. We use these techniques to [1] map genes of interest to specific chromosomal regions, [2] characterize and define aberrant chromosomal material or chromosomal material of unknown origin [3] make karyotype/phenotype correlations [4] investigate DNA copy number changes in various neoplastic specimens such as uterine leiomyosarcomas, uterine leiomyomas and endometrial polyps.





Service Activities

Director of the Clinical Cytogenetics Laboratory at the New York-Presbyterian Hospital
Co-Director of the Laboratory of Personalized Genomic Medicine.
Selected Publications

Levy B, Norwitz E. Non-invasive prenatal aneuploidy testing: technologies and clinical implication. MLO Med Lab Obs 2013;45:8,10,12.

Forman EJ, Hong KH, Ferry KM, Tao X, Taylor D, Levy B, Treff NR, Scott, Jr. RT. In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial. Fertil Steril. 2013 Jul;100(1):100-7.

Reddy U, Page G, Saade G, Silver R, Thorsten V, Parker C, Pinar H, Willinger M, Stoll B, Heim-Hall J, Varner M, Goldenberg R, Bukowski R, Wapner R, Drews-Botsch C, O’Brien B, Dudley D, Levy B. Karyotype versus microarray testing for genetic abnormalities after stillbirth. NEJM. Dec 6, 2012. 367;23:2185-2193.

Wapner R, Martin C, Levy B, Ballif B, Eng C, Zachary J, Savage M, Platt L, Saltzman D, Grobman W, Klugman S, Scholl T, Simpson JL, McCall K, Aggarwal V, Bunke B, Nahum O, Patel A, Lamb A, Thom E, Beaudet A, Ledbetter D, Shaffer L, Jackson L. Chromosomal microarray versus karyotyping for prenatal diagnosis. NEJM. Dec 6, 2012. 367;23:2175-2184.

Zimmermann B, Hill M, Gemelos G, Demko Z, Banjevic M, Baner J, Ryan A, Sigurjonsson S, Chopra N, Dodd M, Levy B, Rabinowitz M. Noninvasive prenatal aneuploidy testing of chromosomes 13, 18, 21, X, and Y, using targeted sequencing of polymorphic loci. Prenat Diagn. 2012 Dec;32(13):1233-41.

Levy B, Tegay D, Papenhausen P, Tepperberg J, Nahum O, Tsuchida T, Pletcher BA, Ala-Kokko L, Baker S, Frederick B, Hirschhorn K, Warburton P, Shanske A. Tetrasomy 15q26: a distinct syndrome or Shprintzen-Goldberg syndrome phenocopy? Genet Med. 2012 Sep;14(9):811-8. 12.

Shanske AL, Goodrich JT, Ala-Kokko L, Levy B. A new syndromic craniosynostosis with involvement of the spine, long bones, pelvis, and digits: molecular genetic and array analysis. Clin Dysmorphol. 2012 Apr;21(2):69-73.

Torgyekes E, Shanske AL, Anyane-Yeboa K, Nahum O, Pirzadeh S, Blumfield E, Jobanputra V, Warburton D, Levy B. The Proximal Chromosome 14q Microdeletion Syndrome: Delineation of the Phenotype Using High Resolution SNP Oligonucleotide Microarray Analysis (SOMA) and Review of the Literature. Am J Med Genet A. 2011; 155A(8):1884-96.

Treff NR, Tao X, Schillings WJ, Bergh, PA, Scott RT Jr., Levy B. Use of single nucleotide polymorphism microarrays to distinguish between balanced and normal chromosomes in embryos from a translocation carrier. Fertil Steril. 2011 May 14. 24.

Levy B, Wang D, Ullner PM, Engelstad K, Yang H, Nahum O, Chung WK, De Vivo DC. Uncovering Microdeletions in Patients with Severe Glut-1 Deficiency Syndrome Using SOMA. Mol Genet Metab. 100 (2010) 129-135. 25.

Treff NR, Su J, Tao X, Levy B, Scott RT Jr. Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays. Fertil Steril. 2010 Feb 24.

Gorgoulis, V.G., Vassiliou, L.V., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio Jr., R.A., Kastrinakis, N.G., Levy, B.., Kletsas, D., Yoneta, A., Herlyn, M., Kittas, C. and Halazonetis, T.D. Activation of the DNA damage checkpoint is an early event in the natural history of human cancer. Nature 2005;434:907-913.

Menasha, J., Levy, B., Hirschhorn, K., Kardon, N.B. The Incidence and Spectrum of Chromosome Abnormalities in Spontaneous Abortions: New insights from a 12 year study. Genet Med 2005;7(4):251-263.

Levy, B., Dunn, T.M., Kaffe, S., Kardon, N., and Hirschhorn, K. Clinical applications of comparative genomic hybridization. Genet Med 1998;1:4-12.

Current Projects

1. We are currently developing "cytogenetic" microarrays for detection of total aneuploidy, sub-telomeric deletions and common and novel micro-deletions.

2. Aneuploidy analysis of single cells using conventional and array comparative genomic hybridization as well as oligonucleotide microarrays and next generation sequencing platforms. We have been working extensively with whole genome amplification techniques that provide sufficient DNA for downstream analyses.

Honors and Awards

2011 Medical Achievement Award – Bonei Olam
2003-07 NIH (NICHD) Clinical Research Loan Repayment Program Award
2003 The Gaisman Frontiers of Biomedical Sciences Research Innovation Award
1999 Mount Sinai School of Medicine Travel Grant
1989-90 The South African Institute for Medical Research Travel Grant
1988-89 The South African Institute for Medical Research Scholarship
Committees , Council, and Professional Society Memberships

Fellow - American College of Medical Genetics
Diplomate - American Board of Genetic Counseling
Member - American Society of Human Genetics
Member - American Society of Reproductive Medicine
Member - Cancer Cytogenomics Microarray Consortium
Member - American Cytogenetics Conference

2002/2012: Certification by the American Board of Medical Genetics' Clinical Cytogenetics
1993: Certification by the American Board of Genetic Counseling
2012 – Present: President, Cancer Cytogenomics Microarray Consortium (CCMC)
2013 – Present: Editorial Board: International Journal of Medical Genetics
2012 – 2013: Editorial Board: Section Editor (Genetics): Journal of Biomedical Research International
2009 – 2012: Editorial Board: Section Editor (Genetics): Journal of Biomedicine and Biotechnology
1999 - July 2005: Continued Medical Education (CME) Advisory Board, Mount Sinai School of Medicine
2005 - Present: Site Visitor for the American Board of Genetic Counseling
2005 - 2008: Item writer for the American Board of Medical Genetics
June 2005: NIH GCAT Study Section, Ad Hoc member
Keywords

Reproductive Genetics
Noninvasive prenatal testing (NIPT)
SNP oligonucleotide microarray analysis (SOMA)
Preimplantation genetic diagnosis (PGD)

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