Research Faculty

Address
630 West 168th Street
VC 15-R204
New York, NY 10032


Phone: 212-305-6941
Fax: 212-305-3429

erv1@cumc.columbia.edu
Education and Training
M.D., University of Bucharest Medical School, Romania


Affiliations
Immunology
Transplant
Elena Rodica Vasilescu, M.D.
Assistant Professor of Clinical Pathology
Research Summary

Polymorphism of HLA in the Romanian population.

We have investigated the HLA-class I and class II polymorphism in a population of 83 Romanians using conventional serology together with PCR amplification and oligonucleotide typing of HLA-class II genes. Romanians show a higher frequency of HLA-A11, B13, B18, B37, B39, B51 and DR2 than other European populations. HLA-DRB1*1501 and 1601 account for the high frequency of the serologic specificity DR2. In Romanians, HLA-DR2 is in linkage disequilibrium with HLA-B18 and HLA-Bw52 rather than with HLA-B7 as in the case in other Europeans. Unexpected HLA-DR2 haplotypes include HLA-DRB1*1502, DQA1*0102, DQB1*0601; HLA-DRB1*1602, DQA1*0102, DQB1*0502. Other unusual haplotypes include HLA-DRB1*0405, DQA1*03, DQB1*0302; HLA-DRB1*1305, DQA1*0103, DQB1*0603; and HLA-DRB1*1405, DQA1*0101, DQB1*05032. Analysis of the genetic distance between Romanians and other Europeans who have been studied serologically are consistent with the hypothesis that Romanians descend from Roman ancestors who colonized Dacia between the 1st century B.C. and 1st century A.D

Pre-and Post-transplantation allosensitization in heart allograft recipients: Major impact of De novo alloantibody production on allograft survival.

We have analyzed the impact of anti-HLA antibodies developed before and/or after transplantation by patients from a cohort of 950 adult recipients of heart allografts performed at our institution between January 1,1995 and December 31,2009.This patient population is uniquebinthat it has been monitoring for anti-HLA antibodies for the entire period of clinical follow-up.
Service Activities

Kidney Transplant Program
Heart Transplant Program
Selected Publications

1. Colovai, A.I., Vasilescu, E.R., Foca-Rodi, A., Kim-Schulze, S., Hussaini, N., D'agati, V., Markowitz, G., Wang, C., Cohen, D., Hardy, M., Suciu-Foca, N. Acute and Hyperacute Humoral Rejection in Kidney Allograft Recipients Treated with Anti-Human Thymocyte Antibodies. Hum Immunol 66:501-12, 2005

2. Colovai, A.C., Foca-Rodi, A., Suciu-Foca, N., and Vasilescu, R. Monitoring of anti-HLA antibodies in renal allograft recipients. Mod Pathology 17(8): 918-27, 2004

3. Suciu-Foaca, N., Vasilescu, E.R., Ho, E., Colovai, A.I., and Mc Manus P., HLA-A and -B allele frequencies in a population from Romania. Hum Immunol 65:1057-1060, 2004

4. Papanikolaou, N.A., Vasilescu, E.R. and Suciu-Foaca, N., Novel Single Nucleotide Polypeptide Polymorphisms in the Human Immune Inhibitory Immunoglobulin-like T cell receptor Type (ILT4). Hum Immunol 65(7):700-5, 2004

5. Vasilescu, E.R., Ho, E.K., De La Torre, L., Itescu, S., Marboe, C., Cortesini, R., Suciu-Foca, N., and Mancini, D. Anti-HLA Antibodies in Heart Transplantation. Transpl Immunol 12:177-83, 2004

6. Ciubotariu, R., Liu, Z., Ho, E., Vasilescu, R., Foca-Rodi, A.,Colovai, A.I., Fisher, P., Hardy, M., Rose, E.A., Cortesini, R., and Suciu-Foca Cortesini, N. Indiresct Allorecognition in Heart Allograft Rejection. Transplantation Proceedings, 33: (1-2)1612, 2001

7. Ciubotariu, R., Vasilescu, R., Ho, E., Cinti, P., Cancedda, C., Poli, L., Late, M., Liu, Z., Berloco, P., Cortesini, R., and Suciu-Foca Cortesini, N., Detection of T Suppressor Cells in Patients with Organ Allografts. Hum Immunol, 62:15-20, 2001

8. Vasilescu, R., Ho, E., McManus, P., Foca-Rodi, A., Reed, E.F., Drugarin, D., and Suciu-Foca N. Romanian Normal. HLA 1998. Terasaki, P., and Gjertson, D.W. eds. Los Angeles, CA, p176, 1998

9. Reed, E., Ho, E., Lupu, F., McManus, P., Vasilescu, R., Foca-Rodi, A., and Suciu-Foca, N. Polymorphism of HLA in the Romanian population. Tissue Antigens 39:8-13, 1992

10. Vasilescu ER,Ho E,Colovai A,Vlad G,Foca-Rodi A,Markowitz,D’Agati V,Hardy M,Ratner L,Suciu_Foca N.Alloantibodies and the outcome of cadaver kidney allograft;Human Immunology 67,597-604(2006)

11. Vlad G,Ho E,Vasilescu ER,Fan EK,Liu J,Cai Z,Junz JW,Buke E,Deng E,Cadeiras M,Cortesini R,Itescu S,Marboe C,Mancini D,Suciu-Foca N. Anti-CD25.Transplant Immunology 18(1):13-21Apr.2007

12.Ho E,Vasilescu ER,Colovai A,Stokes A,Hallar M,Markowitz M,D’Agati GS,Cohen DV,Ratner LD, Suciu-Foca N; Senitivity,Specificity and clinical relevance of different cross-matching assay in deceased-donor renal transplantation;Transplant Immunology2008 Nov:20(1-2).61-7.Epub 2008 Oct16

13.Chang CC,Silvia E,Ho EK,Suciu-Foca N,VasilescuER. Polymorphism and linkage disequilibrium of immunoglobulin-like transcript 3 gene.Human Immunology 02/2008

14.Vlad G,Ho EK,Vailescu ER,Colovai AI,Stockes MB,Markovitz GS,D’Agati VD,Cohen DJ,Ratner DL,Suciu-Foca N. Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased donor kidney survival.Human Immunology.2009 Aug:70(8);589-94.Epub2009Apr15
PMID:19375470(Pub-indexed for MEDLINE)

15. Vlad G,Stokes MB,Chang Z, Sondermeijer CC, Vasilescu ER,Colovai AI,Berloco P,D’Agati VD,Ratner L,Cortesini R,Suciu-Foca N.Suppressor of xenogeneic graft-versus-host disease by treatment with immunoglobulin –like transcript 3Fc.Human Immunology 2009 Sep:70(9);663-9.Epub 2009 Jun6
PMID:19501624(PubMed0indexed for MEDLINE)

16.Ho EK,Vlad G,Colovai AI,Vasilescu ER, Schwartz J,Sondermeijer H,Burke E,Marboe CC,Itescu S,Suciu-Foca N,Mancini D.Alloantibodies in heart transplantation.Human Immunology.2009 Oct;70(10).825-9,Epub 2009 Jun 23 PMID:19555730(PubMed-indexed for MEDLINE)

17.Ho EK,Vlad G,Vasilescu ER,DelaTorre L,Colovai AI,Burk E,Deng M,Schartz J,Marboe C,Mancini D,Opelz G, Suciu Foca N.Pre and Post transplantation allosensitization in heart allograft recipients;major impact of de novoalloantibody pordudustion on allograft survival.Human Immunol.2011 Jan,72(1);5-10.Epub2010Nov10
PMID;20981146(Pubmed-indexed for MEDLINE)

18. Ho EK,Vasilescu ER,Vlad G,Marboe CC,Addonozio LJ,Suciu-FocaN.HLA antibodies in pediatric heart transplantation.Pediatr.Transplant.2011 Aug;15(5);458-64.Epub 2011 Mar 30
PMID;21450008(PubMed0indexed for MEDLINE)

19. Shahzad K,Aziz QA,Leva JP, Cadeiras M Ho EK,Vlad G,Vasilescu ER, Latif F, Sinha E Addonizio LJ,Reastaino SW,Marboe CC,Suciu-Foca N,Naka Y, Mancini D, Deng MC.New-onset graft dysfunction after heart transplantation-incidence and mechanism-related outcome.JHeart Lung Transplantation 2011 Feb:30(2);194-2003 doi:10,1016/J.healun2010.08.026.Epub2010Oct16
PMID:20952209(PubMed-indexed for MEDLINE)

Current Projects

Evaluation of C1q Luminex Assay in patients with Antibody Mediated Rejection


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