As a basic investigator who cares for pediatric cancer patients, my overall goal has been to understand the pathobiology of childhood tumors for the direct benefit of children. Thus, my research has involved both the dissection of basic mechanisms in the laboratory and the translation of these findings to pediatric oncology. My main research focus has been on angiogenesis and the tumor microenvironment in neuroblastoma. We have examined the role of vascular endothelial growth factor (VEGF) and the Notch signaling pathway in angiogenesis. We are also investigating the effects of high dose radiation on the tumor vasculature.
Jani A, Shaikh F, Barton S, Willis C, Banerjee D, Mitchell J, Hernandez SL, Hei T, Kadenhe-Chiweshe A, Yamashiro DJ
, Connolly EP. High-dose, single-fraction irradiation rapidly reduces tumor vasculature and perfusion in a xenograft model of neuroblastoma. International journal of radiation oncology, biology, physics
. 2016. Epub December 28, 2015
Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ
. Notch suppresses angiogenesis and progression of hepatic metastases. Cancer Res
. 2015 Apr 15;75(8):1592-602. PubMed PMID: 25744722; PubMed Central PMCID: PMC4401639.
Hernandez SL, Banerjee D, Garcia A, Kangsamaksin T, Cheng WY, Anastassiou D, Funahashi Y, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ
. Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis. Vasc Cell
. 2013 Sep 25;5(1):17. PubMed PMID: 24066611; PubMed Central PMCID: PMC3849070.
1. Combined effect of high-dose radiation and Notch blockade on the tumor vasculature.
2. Therapeutic Targeting of ATF5 in pediatric solid tumors with a cell penetrating dominant negative ATF5 (collaboration with Drs. Greene and Siegelin)
3. TFAP4 is a master regulator and synthetically lethal to MYCN-amplified neuroblastoma
Neuroblastoma, Notch, VEGF, radiation