Research Faculty

630 West 168th Street,
PH15 Stem-124
New York, NY 10032

Phone: 212-305-4531
Fax: 212-305-4548
Education and Training
Kinki University School of Medicine and Graduate School, Osaka, Japan

Research collaboration with Houston Merritt Clinical Research Center for Muscular Dystrophies and Related Diseases, Department of Neurology, Columbia University
Research collaboration with Sergievsky Center, Department of Neurology, Columbia University
Research collaboration with Dr. M. Lisanti, Department of Pharmacology, Albert Einstein College of Medicine
Kurenai Tanji, M.D., Ph.D.
Professor of Clinical Pathology & Cell Biology
Director, Neuromuscular Pathology Laboratory, Division of Neuropathology
Research Summary

Clinical Research for mitochondrial encephalomyopathies including biochemistry, morphology, and genetics.
Service Activities

Surgical neuropathology service, Neuromuscular diagnostic service, and Brain autopsy service
Selected Publications

Tanji K, Bonilla E. Neuropathologic aspects of cytochrome c oxidase deficiency. Brain Pathol. 2000;10:422-430.

Tanji K, Schon EA, DiMauro S, Bonilla E. Kearns-Sayre syndrome: oncocytic transformation of choroid plexus epithelium. J. Neurol. Sci. 2000;178:29-36.

Tanji K, Kunimatsu T, Vu TH, Bonilla E. Neuropathological features of mitochondrial disorders. Semin. Cell & Dev. Biol. 2001;12:429-439.

Tanji K, Gamez J, Cervera C, Mearin F, Ortega A, Torre J, Montoya J, Andreu AL, DiMauro S, Bonilla E. The A8344G mutation in mitochondrial DNA associated with stroke-like episodes and gastrointestinal dysfunction. Acta Neuropathol. 2003;105:69-75.

Akman H, Dorado B, Lopez LC, Garcia-Cazorla A, Vila MR, Tanabe LM, Dauer WT, Bonilla E, Tanji K, Hirano M. Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenace. Hum Mol Genet 2008; 17(16): 2433 – 2440.

Lopez LC, Akman HO, Garcia-Cazorla A, Dorado B, Marti R, Nishino I, Tadesse S, Pizzorno G, Shungu D, Tanji K, Hirano M. Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice. Hum Mol Genet 2009; 18(4): 714-722.

Tanji K. Morphological evaluation of mitochondria in tissue. In Biochemical and Molecular Analysis of Mitochondrial Disorders. Edited by Wong LJ. Humana Press 2012, pp.181-194.

Emmanuele V, Garcia-Cazorla A, Huang HB, Coku J, Dorado B, DiMauro S, Tanji K. Decreased hippocampal expression of calbindin D28KD and cognitive impairment in MELAS. J Neurol Sci 2012; 317:29-34.

Melia M, Kubota A, Ortolano S, Vilchez JJ, Gamez J, Tanji K, Bonilla E, Palenzuela Lluis, Fernandez-Cadenas I, Pristoupilava A, Garcia-Arumi E, Andreu LA, Navaro C, Hirano M and Marti R. Limb-girdle muscular sytrophy1F (LGMD1F) is casued by a microdeletion in the transporin-3 gene. Brain 2013; 136(Pt5):1508-17.

Tsankova NM, Bevan C, Jobanputra V, Ko YC, Mayer EW, Lefkowitch JH, Mansukhani M, Rowland LP, Bhagat G, Tanji K. Peripheral T-cell lymphoma emerging in a patient with aggressive polymyositis: molecular evidence for neoplastic transformation of an oligoclonal T-cell infiltrate. Acta Neuropathol (2013);126(4):595-601.

Current Projects

1. Investigation upon pathogenesis of strokes in MELAS.
2. Investigation upon mitochondrial functions in Alzheimer's disease and aging.
3. Investigation upon caveolin-related myopathies.

Committees , Council, and Professional Society Memberships

American Association of Neuropathologists

Japanese Society of Pathology

Neuromuscular, Mitochondrial encephalomyopathies, Brain
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