Research Faculty

Address
630 West 168th Street,
VC 14-215
New York, NY 10032

Phone: 212-305-6719
Fax: 212-305-2301

her2007@cumc.columbia.edu
Education and Training
Medical School - Northwestern Univ Medical School
Residency - University of California Los Angeles
Fellowship - Armed Forces Institute, GI/Hepatic Pathology

Affiliations
Enviromental & Health Sciences
Gastointerstinal
Herbert Irving Center
Liver
Transplant



Collaborations
School of Public Health, Environmental Health Science, Molecular Epidemiology
Pancreas Center
Transplantation Center

Helen Remotti, M.D.
Assistant Professor of Clinical Pathology
Research Summary

One of my primary functions as a surgical pathologist at Columbia University involves diagnosing, staging, and grading a large number and unique spectrum of pancreatobiliary hepatic and gastrointestinal tumors. My central focus lies in characterizing morphologic, immunophenotypic and molecular alterations occurring in different subtypes of cancers and their corresponding precursor lesions in human tumors and comparing them with alterations occurring in mouse models. Earlier detection and characterization of carcinoma and its precursor lesions is of critical importance, in addition to developing new therapies that will improve the clinical outcome for these tumors.
Selected Publications

1. Winner, M., Epelboym, I., Remotti, H., Lee, J. L., Schrope, B. A., Chabot, J. A., and Allendorf, J. D. (2013) Predictors of recurrence in intraductal papillary mucinous neoplasm: experience with 183 pancreatic resections, J Gastrointest Surg 17, 1618-1626.

2. Shen, J., Wang, S., Zhang, Y. J., Wu, H. C., Kibriya, M. G., Jasmine, F., Ahsan, H., Wu, D. P., Siegel, A. B., Remotti, H., and Santella, R. M. (2013) Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips, Epigenetics 8, 34-43.

3. Shen, J., Wang, A., Wang, Q., Gurvich, I., Siegel, A. B., Remotti, H., and Santella, R. M. (2013) Exploration of Genome-Wide Circulating MicroRNA in Hepatocellular Carcinoma: MiR-483-5p as a Potential Biomarker, Cancer Epidemiol Biomarkers Prev.

4. Remotti, H. (2013) Tissue microarrays: construction and use, Methods Mol Biol 980, 13-28.

5. Lagana, S. M., Salomao, M., Bao, F., Moreira, R. K., Lefkowitch, J. H., and Remotti, H.E. (2013) Utility of an immunohistochemical panel consisting of glypican-3, heat-shock protein-70, and glutamine synthetase in the distinction of low-grade hepatocellular carcinoma from hepatocellular adenoma, Appl Immunohistochem Mol Morphol 21, 170-176.

6. Gunturu, K. S., Woo, Y., Beaubier, N., Remotti, H.E., and Saif, M. W. (2013) Gastric cancer and trastuzumab: first biologic therapy in gastric cancer, Ther Adv Med Oncol 5, 143-151.

7. Garcia-Carracedo, D., Turk, A. T., Fine, S. A., Akhavan, N., Tweel, B. C., Parsons, R., Chabot, J. A., Allendorf, J. D., Genkinger, J. M., Remotti, H.E., and Su, G. H. (2013) Loss of PTEN Expression Is Associated with Poor Prognosis in Patients with Intraductal Papillary Mucinous Neoplasms of the Pancreas, Clin Cancer Res. November 12.

8. Siegel, A. B., Lim, E. A., Wang, S., Brubaker, W., Rodriguez, R. D., Goyal, A., Jacobson, J. S., Hershman, D. L., Verna, E. C., Zaretsky, J., Halazun, K., Dove, L., Brown, R. S., Jr., Neugut, A. I., Kato, T., Remotti, H., Coppleson, Y. J., and Emond, J. C. (2012) Diabetes, body mass index, and outcomes in hepatocellular carcinoma patients undergoing liver transplantation, Transplantation 94, 539-543.

9. Salomao, M., Remotti, H., Vaughan, R., Siegel, A. B., Lefkowitch, J. H., and Moreira, R. K. (2012) The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis, Hum Pathol 43, 737-746.

10. Remotti, H.E., Winner, M., and Saif, M. W. (2012) Intraductal papillary mucinous neoplasms of the pancreas: clinical surveillance and malignant progression, multifocality and implications of a field-defect, JOP 13, 135-138.

11. Remotti, H., Subramanian, S., Martinez, M., Kato, T., and Magid, M. S. (2012) Small-bowel allograft biopsies in the management of small-intestinal and multivisceral transplant recipients: histopathologic review and clinical correlations, Arch Pathol Lab Med 136, 761-771.

12. Qiu, W., Sahin, F., Iacobuzio-Donahue, C. A., Garcia-Carracedo, D., Wang, W. M., Kuo, C. Y., Chen, D., Arking, D. E., Lowy, A. M., Hruban, R. H., Remotti, H.E., and Su, G. H. (2011) Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo, Oncotarget 2, 862-873.

Current Projects

Two main areas of research interest involve :
1) Small intestinal, Pancreatic and Liver Transplantation – clinical translational studies.
2) Molecular Characterization of Pancreatobiliary , Hepatic and Neuroendocrine Tumors of the Gastrointestinal Tract with a focus on studies that may help guide therapeutic decisions in tailoring patient-specific treatments.


Committees , Council, and Professional Society Memberships

American Association of Cancer Research
American Society of Clinical Oncology
United States and Canadian Academy of Pathology
College of American Pathologists

Keywords

Small bowel transplantation, Pancreas Cancer, Liver Cancer, Neuroendocrine Tumors.

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