Research Faculty

Address
650 West 168th Street
Room 307
New York, NY 10032


Phone: 212-305-1540
Fax: 212-305-5450

sp30@columbia.edu
Education and Training
M.D. 1983
Universit Libre de Bruxelles
Ph.D. 1992
Universit Libre de Bruxelles
Internship 1983-84
Hospital Brugman, University Libre de Bruxelles
Residency, Neurology 1984-88
Hospital Erasme, Universit
Serge Przedborski, M.D., Ph.D.
Professor of Neurology and Pathology
Research Summary

The Molecular Basis of Neurodegeneration and Therapeutic Strategies.
Research is geared toward unraveling the molecular basis of neurodegeneration and devising therapeutic strategies to hamper the processes that cause neuronal death. To that end, we have concentrated our research efforts on the MPTP mouse model of Parkinson's disease (PD) and on the mutant superoxidedismutase-1 (mSOD1) mouse model of amyotrophic lateral sclerosis (ALS). Work in our laboratory has demonstrated that following the administration of the neurotoxin MPTP, the demise of the nigral dopaminergic neurons (the hallmark of PD) depends on the production of the reactive species, nitric oxide (NO), which originates in neighboring neurons and glial cells.
We have also shown that NO does not cause damage directly, but rather by reacting with another reactive species superoxide to produce peroxynitrite - the actual culprit. We have shown that peroxynitrite, once produced, inflicts severe damage on cell proteins and DNA. Cell death is likely to result not only from these injuries, but also from apoptosis. Apoptosis, which is a form of programmed cell death, also appears to play a major role in the degeneration of spinal cord motor neurons in ALS. This view is supported by several recent publications from our laboratory. For example, the expression of key molecular apoptotic factors is altered in transgenic mSOD1 mice in a way that promotes cell death.

Through genetic and pharmacological interventions aimed at alleviating these noxious changes, one of our teams was able to prolong survival and attenuate neuronal death in this mouse model of ALS. This beneficial effect is, in part, mediated by the prevention of the release of cytochrome c from the mitochondria, which triggers a cascade of deleterious events implicated in the death of motor neurons.

Selected Publications

Please click the PubMed link below to view Dr. Przedborski's publcations:

Honors and Awards

1983
Graduated M.D. degree with "summa cum laude" from University Libre de Bruxelles, Belgium

1990
Neurosciences Award at the International Congress of Movement Disorders

1998
The Doctor Harold and Golden Lamport Award for Excellence in Clinical Science Research

1999-2003
Editorial Board Member of Movement Disorder

2000-
Editorial Board Member of the Journal of Neurochemistry

2000-2002
Member of the Scientific Committee of the Huntington's Disease Society of America

2001-present
Member of the Education subcommittee for the Annual Meeting of the American Academy of Neurology

2001-present
Member of the Scientific Committee of the Muscular Disease Association

2001
The Schmitt Lecture (Program in Integrative Brain Research), U. Rochester, NY

2001-present
Regular Member of the NINDS Study Section NSD-B

2002
The Sheila Essey Award for ALS Research (the American Academy of Neurology)

Keywords

methylphenyltetrahydropyridine, neural degeneration, neurotoxin, nitric oxide, nitrogen compound, substantia nigra, tyrosine, Parkinson's disease, disease /disorder model, enzyme activity, manganese, molecular pathology, nitric oxide synthase, oxygenase, p
top
 
 
Contact the Pathology Webmaster at PathWebMaster@columbia.edu