Research Faculty

Address
1130 St. Nicholas Ave
Irving Cancer Research Center
Room 508
New York, NY 10032
Phone: 212-851-5273
Fax: 212-851-5256

rd10@cumc.columbia.edu
Riccardo Dalla-Favera, M.D.
Director, Institute for Cancer Genetics;
Percy and Joanne Uris Professor of Clinical Medicine;
Professor of Pathology and Cell Biology
Professor of Genetics & Development
Professor, Microbiology & Immunology
Research Summary

Molecular Pathogenesis of Human B Cell Tumors.
The development of many types of cancer is due to genetic lesions involving proto-oncogenes and tumor suppressor genes. It is well established that multiple lesions must occur in a cell before cancer can develop. The general goal of this laboratory is to identify the lesions and the genes involved in the development of human B cell lymphoma, to determine the mechanism by which these lesions occur and to elucidate the contribution of each lesion to tumor development using mouse models.


Affiliations

Genetics & Development
Institute for Cancer Genetics
MD-PhD Program
Microbiology
Selected Publications

1. Basso K, Sumazin P, Morozov P, Schneider C, Maute RL, Kitagawa Y, Mandelbaum J, Haddad J Jr, Chen CZ, Califano A, Dalla-Favera R. Identification of the human mature B cell miRNome. Immunity 30(5):744-52, 2009

2. Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q, Bertoni F, Ponzoni M, Scandurra M, Califano A, Bhagat G, Chadburn A, Dalla-Favera R, Pasqualucci L. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature 459:717-21, 2009

3. Klein, U., Lia, M., Crespo, M., Siegel, R., Shen, Q., Mo, T., Ambesi-Impiombato, A., Califano, A., Migliazza, A., Bhagat, G., Dalla-Favera, R. The DLEU2/miR-15a/16-1 cluster controls B-cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 17(1):28-40, 2010

4. Mandelbaum, J., Bhagat, G., Tang, H., Mo, T., Brahmachary, M., Shen, Q., Chadburn, A., Rajewsky, K., Tarakhovsky, A., Pasqualucci L., and Dalla-Faver,a R. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B-cell like diffuse large B cell lymphoma. Cancer Cell 18(6):568-79, 2010

5. Pasqualucci, L., Dominguez-Sola, D., Chiarenza, A., Fabbri, G., Grunn, A., Trifonov, V., Kasper, L.H., Lerach, S., Tang, H., Ma, J., Rossi, D., Chadburn, A., Vundavalli, V., Murty, Mullighan, C.G., Gaidano, G., Rabadan, R., Brindle, P.K., Dalla-Favera, R. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 471(7337):189-95, 2011

6. Pasqualucci, L., Trifonov, V., Fabbri, G., Ma, J., Rossi, D., Chiarenza, A., Wells, V.A., Grunn, A., Messina, M., Elliot, O., Chan, J., Bhagat, G., Chadburn, A., Gaidano, G., Mullighan, C.G., Rabadan, R., Dalla-Favera, R. Analysis of the coding genome of diffuse large B cell lymphoma. Nature Genetics 43(9):830-7, 2011

7. Challa-Malladi, M., Lieu, Y.K., Califano, O., Holmes, A., Bhagat, G., Dominguez-Sola, D., Murty, V.V., Pasqualucci, L., Dalla-Favera, R. Combined Genetic Inactivation of Beta2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B-cell Lymphoma. Cancer Cell 13:20(6):728-40, 2011

8. Dominguez-Sola, D., Dalla-Favera, R. Burkitt Lymphoma:Much More than MYC. Cancer Cell 22(2):141-2, 2012

9. Dominguez-Sola, D., Victora, G.D., Ying, C.Y., Phan, R.T., Saito, M., Nussenzweig, M.C., Dalla-Favera, R. The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol 13(11):1083-91, 2012

10. Ying, C.Y., Dominguez-Sola, D., Fabi, M., Lorenz, I.C., Hussein, S., Bansal, M., Califano, A., Pasqualucci, L., Basso, K., Dalla-Favera, R. MEF2B mutations lead to deregulated expression of the BCL6 oncogene in diffuse large B cell lymphoma. Nat Immunol 10:1084-92, 2013

Current Projects

Specific lines of investigation include:

(1) Analysis of the signaling and transcriptional networks regulating the development of germinal centers (GC), the structure from which most B cell lymphomas derive

(2) Studying the normal and pathologic function of the BCL-6 gene, a proto-oncogene which codes for a transcription factor expressed in GC B cells, required for GC formation, and altered in its regulatory region in a significant fraction of human lymphoma.

(3) Identifying novel oncogenes and tumor suppressors involved in the pathogenesis of B cell lymphoma by genome-wide analysis

(4) Use bioinformatics tool and mouse models to understand the specific role of the genetic lesions identified in (3) and their relationships in lymphomagenesis.

(5) Pre-clinical testing of drugs targeting the pathways identified in (3-4)

Honors and Awards

1984 - Leukemia Society of America Scholar

1989 - N.I.H., MERIT Award

1994 - Annual Guest Lecture Award, Leukemia Research Fund, U.K.

1998 - Fellow, American Association of

2002 - N.I.H., MERIT Award

2005 - Outstanding Achievement Award, American-Italian Cancer Foundation

2006 - William Dameshek Prize, American Society of Hematology

2008 - Sir John Dacie Lecture Award, Imperial College, London UK

2010 - San Salvatore Foundation Prize for Lymphoma Research

2010 - Member, Institute of Medicine, National Academy of Sciences

2012 - Alfred Knudson Award, National Cancer Institute

Committees , Council, and Professional Society Memberships

2010 - Co-Chairman, Scientific Advisory Board, American-Italian Cancer Foundation
2011 - Member, Scientific Advisory Board, Cancer Genetics Inc.
2007 - Journal of Clinical Investigation (Consulting Editor)
2012 - Cancer Cell (Editorial Board)

top
 
 
Contact the Pathology Webmaster at PathWebMaster@columbia.edu