Research Faculty

Address
630 West 168th Street
P&S 17-401
New York, NY 10032


Phone: 212-305-9706
Fax:

mm322@cumc.columbia.edu
Education and Training
1985 M.D., Davao Medical School, Philippines

AP/CP - Columbia Presbyterian
Medical Center

Board Certifications:
American Board of Pathology -
AP/CP - March 1998.
American Board of Pathology/
Amercian College of Medical Genetics -
Molecular Genetic Pathology,
September 2003.

Training Activities
Molecular Genetic Pathology Fellowship Program
Clinical Genetics Fellowship Program
Clinical Molecular Genetics Training Program
Mahesh Mohandas Mansukhani, M.D.
Associate Professor of Clinical Pathology at CUMC
Research Summary

I am involved in collaborative research involving the use of diagnostic/prognostic/predictive biomarkers in cancer, especially genitourinary cancer, and in the application of new technologies for the diagnosis of cancer and genetic diseases.

Service Activities

Director, Division of Personalized Genomic Medicine


Affiliations
Hematopathology
Institute for Cancer Genetics
Molecular Genetic Pathology
Selected Publications

1. Tsankova NM, Bevan C, Jobanputra V, Ko YC, Mayer EW, Lefkowitch JH, Mansukhani M, Rowland LP, Bhagat G, Tanji K. Peripheral T-cell lymphoma emerging in a patient with aggressive polymyositis: molecular evidence for neoplastic transformation of an oligoclonal T-cell infiltrate. Acta Neuropathol. 2013;126:595-601. Epub 2013 Aug 13.


2. Lee JC, Hoehn D, Schecter J, Murty VV, Mansukhani MM, Alobeid B, Bhagat G. Lymphoid follicle colonization by Bcl-2(bright+)CD10(+) B-cells ("follicular lymphoma in situ") at nodal and extranodal sites can be a manifestation of follicular homing of lymphoma. Hum Pathol. 2013 Jan 28. [Epub ahead of print]

3. Shu C, Cheng H, Wang A, Mansukhani MM, Powell CA, Halmos B, Borczuk AC. Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung. Mod Pathol. 2013;26:239-46. Epub 2012 Sep 21.

4. Wosnitzer MS, Hruby GW, Murphy AM, Barlow LJ, Cordon-Cardo C, Mansukhani M, Petrylak DP, Benson MC, McKiernan JM. A comparison of the outcomes of neoadjuvant and adjuvant chemotherapy for clinical T2-T4aN0-N2M0 bladder cancer. Cancer. 2012;118:358-64. Epub 2011 Jun 29.

5. Ewalt M, Nandula S, Phillips A, Alobeid B, Murty VV, Mansukhani MM, Bhagat G. Real-time PCR-based analysis of BRAF V600E mutation in low and intermediate grade lymphomas confirms frequent occurrence in hairy cell leukaemia. Hematol Oncol. 2012;30:190-3 Epub 2011 Dec 22.

6. Wosnitzer MS, Domingo-Domenech J, Castillo-Martin M, Ritch C, Mansukhani M, Petrylack DP, Benson MC, McKiernan JM, Cordon-Cardo C. Predictive value of microtubule associated proteins tau and stathmin in patients with nonmuscle invasive bladder cancer receiving adjuvant intravesical taxane therapy. J Urol. 2011;186:2094-100. Epub 2011 Sep 23

7. Tong GX, Memeo L, Colarossi C, Hamele-Bena D, Magi-Galluzzi C, Zhou M, Lagana SM, Harik L, Oliver-Krasinski JM, Mansukhani M, Falcone L, Hibshoosh H, O'Toole K. PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract. Am J Surg Pathol. 2011;35:1473-83.

8. Wosnitzer MS, Hruby GW, Murphy AM, Barlow LJ, Cordon-Cardo C, Mansukhani M, Petrylak DP, Benson MC, McKiernan JM. A comparison of the outcomes of neoadjuvant and adjuvant chemotherapy for clinical T2-T4aN0-N2M0 bladder cancer. Cancer. 2011 Jun 29. [Epub ahead of print]

9. Sevilla DW, Murty VV, Sun XL, Nandula SV, Mansukhani MM, Alobeid B, Bhagat G. Cytogenetic abnormalities in reactive lymphoid hyperplasia: byproducts of the germinal centre reaction or indicators of lymphoma? Hematol Oncol. 2011;29:81-90. Epub 2010 Aug 5.

10. Mordukhovich I, Rossner P, Terry MB, Santella R, Zhang YJ, Hibshoosh H, Memeo L, Mansukhani M, Long CM, Garbowski G, Agrawal M, Gaudet MM, Steck SE, Sagiv SK, Eng SM, Teitelbaum SL, Neugut AI, Conway-Dorsey K, Gammon MD. Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors. Environ Health Perspect. 2010;118:511-8. Epub 2009 Nov 18.

11. Sireci AN, Crapanzano JP, Mansukhani M, Wright T, Babiac A, Erroll M, Vazquez M, Saqi A. Atypical glandular cells (AGC): ThinPrep imaging system (TIS), manual screening (MS), and correlation with Hybrid Capture 2 (HC2) HPV DNA testing. Diagn Cytopathol. 2010;38:705-9

12. Petrylak DP, Tangen CM, Van Veldhuizen Jr PJ, Goodwin JW, Twardowski PW, Atkins JN, Kakhil SR, Lange MK, Mansukhani M, Crawford ED. Results of the Southwest Oncology Group phase II evaluation (study S0031) of ZD1839 for advanced transitional cell carcinoma of the urothelium. BJU Int. 2010;105:317-21. Epub 2009 Nov 2

13. Vakiani E, Arguelles-Grande C, Mansukhani MM, Lewis SK, Rotterdam H, Green PH, Bhagat G. Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients. Mod Pathol. 2010;23:12-26. Epub 2009 Oct 23


Monograph Chapters/Editorials:

1. Mansukhani MM and Mazziotta R Molecular Pathology Diagnostics, in Anatomic Pathology Board Review (Lefkowitch J, ed). Elsevier 2006. in press.

2. Mansukhani MM and Remotti F. Immunopathology, in Anatomic Pathology Board Review (Lefkowitch J ed). Elsevier 2006. in press.

3. Hibshoosh H and Mansukhani M. Molecular Pathology of Breast Cancer, in Textbook of Breast Cancer: A Clinical Guide to Therapy (Bonadonna G, Hortobagyi GN and Gianni AM eds.) London: Martin Dunitz 2001 pp. 49-62

4. Mansukhani, M., Greenebaum E: Loss of Heterozygosity Analysis to Distinguish Adrenal Cortical Adenoma from Carcinoma: Are we there yet? Cancer (Cancer Cytopathol.) 1999; 87:173-175.

Committees , Council, and Professional Society Memberships

Association for Molecular Pathology

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