W. Ian Lipkin, MD, is internationally recognized as an authority on the use of molecular methods for pathogen discovery and the role of infection in neurologic and neuropsychiatric diseases.
Dr. Lipkin has over 30 years of experience in diagnostics, microbial discovery and outbreak response. He has mentored and trained over 30 students and post-doctoral fellows and leads a workforce of over 65 principal investigators, post-doctoral fellows and research and support staff with expertise in sample and database management, bioinformatics, biostatistics, diagnostics, molecular biology, experimental pathology, serology, culture, animal models, and staged strategies for efficient pathogen discovery and proof of causation.
In the 1980s, Dr. Lipkin identified AIDS-associated immunological abnormalities and inflammatory neuropathy, which he showed could be treated with plasmapheresis, and demonstrated that early life exposure to viral infections affects neurotransmitter function. Dr. Lipkin was the first to use purely molecular methods to identify infectious agents. In 1999, he identified West Nile virus as the cause of encephalitis in North America. He developed MassTag PCR and Greenechip technology, two multiplex assays that have been used to identify and characterize more than 400 viruses, and was the first to use high throughput sequencing for pathogen discovery. In 2003, Dr. Lipkin established the Norwegian Autism Birth Cohort (ABC), the largest prospective birth cohort devoted to investigating gene-environment-timing interactions and biomarker discovery.
His honors include the National Alliance for Research on Schizophrenia and Depression Young Investigator Award, Fellow of the New York Academy of Sciences, Distinguished Lecturer of the Nation Center for Infectious Diseases, Honorary and Founding Director of the Beijing Center for Infectious Diseases, Fellow of the American Society for Microbiology, Fellow of the Wildlife Conservation Society, Fellow of the American Association for the Advancement of Science, Member of the Association of American Physicians and Member of the NIH Advisory Committee to the Director. He has been featured by the New York Times, the Los Angeles Times, Discover Magazine, Nature Medicine, the History Channel, National Geographic, National Public Radio, Wired, the Huffington Post, This Week in Virology, WNYC, Through the Wormhole with Morgan Freeman and Steven Soderbergh's upcoming film Contagion
.Photo courtesy: Columbia Technology Ventures
, Travis GH, Carbone KM, Wilson MC (1990) Isolation and characterization of Borna disease agent cDNA clones. Proc. Natl. Acad. Sci. U.S.A., 87, 4184-4188.
Briese T, Schneemann A, Lewis AJ, Park Y, Kim S, Ludwig H, Lipkin WI
(1994) Genomic organization of Borna disease virus. Proc. Natl. Acad. Sci. U.S.A., 91, 4362-4366.
Hornig M, Weissenbock H, Horscroft N, Lipkin WI
(1999) An infection-based model of neurodevelopmental damage. Proc. Natl. Acad. Sci. U.S.A., 96, 12102-12107.
Jia X-Y, Briese T, Jordan I, Rambaut A, Chi HC, Mackenzie JS, Hall RA, Scherret J, Lipkin WI
(1999) Genetic analysis of the West Nile New York 1999 encephalitis virus. Lancet, 354, 1971-1972.
Lamson D, Renwick N, Kapoor V, Liu Z, Palacios G, Ju J, Dean A, St. George K, Briese T, Lipkin WI
(2006) MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, causing influenza-like illness in New York State, 2004-2005/ J Infectious Dis, 15, 1398.
Cox-Foster DL, Conlan S, Holmes EC, Palacios G, Evans JD, Moran NA, Quan P-L, Briese T, Hornig M, Geiser DM, Martinson V, vanEngelsdorp Dennis,, Kalkstein AL, Drysdale A, Hui J, Zhai J, Cui L, Hutchison SK, Simons JF, Egholm M, Pettis JS, Lipkin WI
(2007) A metagenomic survey of microbes in honey bee colony collapse disorder. Science, 318, 283.
Palacios G, Druce J, Du L, Tran T, Birch C, Briese T, Conlan S, Quan P-L, Hui J, Marshall J, Simons JF, Egholm M, Ierino F, Swaminathan A, Walker R, Angus P, Paddock CD, Shieh W-J, Zaki S, Catton M, Lipkin WI
(2008) Discovery and implication of a novel arenavirus in a cluster of fatal transplant associated disease. NEJM, 358, 991
Briese T, Paweska JT, McMullan LK, Hutchison SK, Street C, Palacios G, Khristova ML, Weyer J, Swanepoel R, Egholm E, Nichol ST, Lipkin WI
(2009) Genetic detection and characterization of LuJo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. PLoS Pathog, 5(5):e1000455.
Kapoor A, Simmonds P, Gerold G, Qaisar N, Jain K, Henriquez JA, Firth C, Hirschberg DL, Rice CM, Shields S, Lipkin WI
. Characterization of a canine homolog of hepatitis C virus. PNAS 2011 Jul 12;108(28):11608-13.
Alter HJ, Mikovits JA, Switzer WM, Ruscetti FW, Lo SC, Klimas N, Komaroff AL, Montoya JG, Bateman L, Levine S, Peterson D, Levin B, Hanson MR, Genfi A, Bhat M, Zheng H, Wang R, Li B, Hung GC, Lee LL, Sameroff S, Heneine W, Coffin J, Hornig M, Lipkin WI
. A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus. mBio. 2012;3(5).
Memish ZA, Mishra N, Olival KJ, Fagbo SF, Kapoor V, Epstein JH, Alhakeem R, Durosinloun A, Al Asmari M, Islam A, Kapoor A, Briese T, Daszak P, Al Rabeeah AA, Lipkin WI
. Middle East respiratory syndrome coronavirus in bats, Saudi Arabia. Emerging infectious diseases. 2013 Nov;19(11).
Anthony SJ, Epstein JH, Murray KA, Navarrete-Macias I, Zambrana-Torrelio CM, Solovyov A, Ojeda-Flores R, Arrigo NC, Islam A, Ali Khan S, Hosseini P, Bogich TL, Olival KJ, Sanchez-Leon MD, Karesh WB, Goldstein T, Luby SP, Morse SS, Mazet JA, Daszak P, Lipkin WI
. A strategy to estimate unknown viral diversity in mammals. mBio. 2013;4(5).