Research Faculty

Address
630 West 168th Street,
VC 14-236,
New York, NY 10032

Phone: 212-342-1323
Fax:

gb96@cumc.columbia.edu
Education and Training
1992 M.B.B.S., University College of Medical Sciences, Delhi University

Affiliations
Hematopathology
Herbert Irving Cancer Center
Govind Bhagat, M.B.B.S
Professor of Clinical Pathology and Cell Biology
Director, Division of Hematopathology
Research Summary

Pathogenesis of non-Hodgkin lymphoma and leukemia.

Immunology and pathology of celiac disease.
Service Activities

Dr. Bhagat is the Director of the Hematopathology Division at Columbia University Medical Center (CUMC).

Division of Hematopathology

The Division of Hematopathology of the Department of Pathology and Cell Biology at CUMC provides a variety of diagnostic services, ranging from morphologic and immunophenotypic analyses, including flow cytometry and immunohistochemistry, to molecular genetic assays for clonality assessment and mutation detection, which provide diagnostic (and prognostic) information, to interpretation of cytogenetic abnormalities associated with hemato-lymphoid neoplasms. The material submitted from various CUMC units and other referring institutes comprises of lymph node or soft tissue biopsies, splenectomy and other tissue resection specimens, bone marrow biopsies, marrow aspirate smears and/or touch preparations, and cytospin preparations of CSF and other body fluids.

The Hematopathology Division also provides consultation to and is integrated with the clinical hematology, coagulation, flow cytometry, and cancer cytogenetics laboratories, which are all part of the Department of Pathology and Cell Biology and are located at the Medical Center. A one-year ACGME accredited fellowship in Hematopathology is offered by the division, which is designed to provide comprehensive training in the diagnosis and classification of a wide range of hematologic diseases and in the principles of molecular pathogenesis of hemato-lymphoid neoplasms.

As Director of the Hematopathology Division, Dr. Bhagat is responsible for supervising administrative, academic, and research activities of the division, training and mentoring of residents, fellows and medical students, and coordinating service activities with other clinical departments.
Selected Publications

Margolskee E, Jobanputra V, Lewis SK, Alobeid B, Green PH, Bhagat G. Indolent Small Intestinal CD4+ T-cell Lymphoma Is a Distinct Entity with Unique Biologic and Clinical Features. PLoS One. 2013, 8(7):e68343.

Lee JC, Hoehn D, Schecter J, Murty VV, Mansukhani MM, Alobeid B, Bhagat G. Lymphoid follicle colonization by Bcl-2(bright+)CD10(+) B-cells ("follicular lymphoma in situ") at nodal and extranodal sites can be a manifestation of follicular homing of lymphoma. Hum Pathol. 2013, 44(7):1328-1340.

DeGaetani M, Tennyson CA, Lebwohl B, Lewis SK, Abu Daya H, Arguelles-Grande C, Bhagat G, Green PH. Villous atrophy and negative celiac serology: a diagnostic and therapeutic dilemma. Am J Gastroenterol. 2013, 108(5):647-653.

Leslie LA, Lebwohl B, Neugut AI, Gregory Mears J, Bhagat G, Green PH. Incidence of lymphoproliferative disorders in patients with celiac disease. Am J Hematol. 2012, 87(8):754-759.

Novak U, Basso K, Pasqualucci L, Dalla-Favera R, Bhagat G. Genomic analysis of Non-Splenic Marginal Zone Lymphomas (MZL) indicates similarities between nodal and extranodal MZL and supports their derivation from Memory B-cells. Br J Haematol. 2011, 155(3):362-365.

Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliot O, Chan J, Bhagat G, Chadburn A, Gaidano G, Mullighan CG, Rabadan R, Dalla-Favera R. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet. 2011, 43(9):830-837.

Sevilla DW, Murty VV, Sun XL, Nandula SV, Mansukhani MM, Alobeid B, Bhagat G. Cytogenetic abnormalities in reactive lymphoid hyperplasia: byproducts of the germinal centre reaction or precursors of lymphoma? Hematol Oncol 2011, 29(2):81-90.

Rinaldi A, Mian M, Chigrinova E, Arcaini L, Bhagat G, Novak U, Rancoita PM, De Campos CP, Forconi F, Gascoyne RD, Facchetti F, Ponzoni M, Govi S, Ferreri AJ, Mollejo M, Piris MA, Baldini L, Soulier J, Thieblemont C, Canzonieri V, Gattei V, Marasca R, Franceschetti S, Gaidano G, Tucci A, Uccella S, Tibiletti MG, Dirnhofer S, Tripodo C, Doglioni C, Dalla Favera R, Cavalli F, Zucca E, Kwee I, Bertoni F. Genome wide DNA-profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Blood. 2011, 117(5):1595-1604.

Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L, Dalla-Favera R. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B-cell like diffuse large B cell lymphoma. Cancer Cell. 2010, 18(6):568-579.

Klein U, Lia M, Crespo M, Siegel R, Shen Q, Mo T, Ambesi-Impiombato A, Califano A, Migliazza M, Bhagat G, Dalla-Favera R. The DLEU2/miR-15a/16-1 cluster controls B-cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell. 2010, 17(1):28-40.

Vakiani E, Arguelles-Grande C, Mansukhani MM, Lewis SK, Rotterdam H, Green PH, Bhagat G. Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients. Mod Pathol. 2010, 23(1):12-26.

Manavalan JS, Hernandez L, Shah JG, Konikkara J, Naiyer AJ, Lee AR, Ciaccio E, Minaya MT, Green PH, Bhagat G. Serum Cytokine Elevations in Celiac Disease: Association with Disease Presentation. Hum Immunol. 2010, 71(1):50-57.

Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q, Bertoni F, Ponzoni M, Scandurra M, Califano A, Bhagat G, Chadburn A, Dalla-Favera R, Pasqualucci L. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature. 2009, 459(7247):717-721.

Novak U, Rinaldi A, Kwee I, Nandula SV, Rancoita PM, Compagno M, Cerri M, Rossi D, Murty VV, Zucca E, Gaidano G, Dalla-Favera R, Pasqualucci L, Bhagat G, Bertoni F. The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas. Blood. 2009, 113(20):4918-4921. G Bhagat and F Bertoni equal contributors

Vakiani E, Basso K, Klein U, Mansukhani MM, Narayan G, Smith PM, Murty VV, Dalla-Favera R, Pasqualucci L, Bhagat G. Genetic and phenotypic analysis of B-cell post-transplant lymphoproliferative disorders provides insights into disease biology. Hematol Oncol. 2008, 26(4):199-211.

Pasqualucci L, Bhagat G, Jankovic M, Compagno M, Smith P, Muramatsu M, Honjo T, Morse HC 3rd, Nussenzweig MC, Dalla-Favera R. AID is required for germinal center-derived lymphomagenesis. Nat Genet. 2008, 40(1):108-112.

Bhagat G, Naiyer AJ, Shah JG, Harper J, Jabri B, Wang TC, Green PH, Manavalan JS. Small intestinal CD8+TCR+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J Clin Invest. 2008, 118(1):281-293.

Committees , Council, and Professional Society Memberships

2008 – present: American Society of Hematology

2005 - present: Society for Mucosal Immunology

2004 - present: Society for Hematopathology

1999 - present: United States and Canadian Academy of Pathology
Keywords

Post-transplant lymphoproliferative disorders, Celiac Disease, intraepithelial lymphocytes, Non-Hodgkin lymphoma, Leukemia.

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