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Research Studies
Alzheimers
| PET Imaging of Mild Cognitive Impairment, Early Alzheimer’s Disease and Healthy Elderly (4863) |
Identifying the magnitude of amyloid plaque formation in human subjects is of enormous clinical value in making an early diagnosis of Alzheimer's Disease (AD) and in monitoring treatment. Further, repeat scanning will be useful to determine its potential utility for monitoring during therapy in the future. We propose to utilize the tracer [11C]-6-OH-BTA-1 in order to assess two patient populations and a control group.
We plan to study amyloid deposits using PET scanning with FDG and [11C]-6-OH-BTA-1 in 20 subjects with mild, early AD, 20 subjects with mild cognitive impairment (MCI), and 20 elderly healthy subjects. We will repeat these procedures at one-year follow-up in 16 subjects with mild, early AD, 16 subjects with mild cognitive impairment (MCI), and 16 elderly healthy subjects. An MRI scan will also be obtained to enable precise mapping of the regions of interest of each subject’s brain.
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| Alzheimer's Disease Neuroimaging Initiative (3599) |
This multi-site study sponsored by the NIH seeks to determine whether imaging of the brain (MRI, PET or CT scans) every six months can help predict and monitor the onset and progression of Alzheimer’s disease. In addition to neuroimaging, the study will collect and test blood and, for some participants, cerebral spinal fluid, to determine if biomarkers can predict and monitor the disease.
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Patients
